CORE 2 DB3: CASPASE-DRIVEN HEMATOPOETIC CELL DIFFERENTIATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 驱动生物学项目3：半胱天冬酶驱动造血细胞分化 淋巴细胞生理学领域的一个新的令人兴奋的发展是发现半胱天冬酶， 除了它们在介导细胞死亡中作用外，还在T细胞活化中起关键和积极的作用 和扩散。一些半胱天冬酶的活化可以在T细胞活化后早期检测到，而一些半胱天冬酶的活化可以在T细胞活化后早期检测到。 胱天蛋白酶底物在没有任何细胞死亡迹象的情况下被裂解。胱天蛋白酶也被证明 是T细胞激活所必需的一种家族性人类免疫缺陷被发现是 由半胱天冬酶8基因的失活突变引起。综合起来，这些数据使我们能够 提出了这样一个假设，即半胱天冬酶在T淋巴细胞生理学中起着允许的作用， 一些细胞蛋白质的蛋白水解加工，这将在该项目中进行测试

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 3: Caspase-driven Hematopoetic Cell Differentiation A new and exciting development in the field of lymphocyte physiology is the finding that caspases, in addition to their role in mediating cell death, also play a critical and positive role in T cell activation and proliferation. Activation of some caspases can be detected early after T cell activation and some caspase substrates are cleaved in the absence of any signs of cell death. Caspases have also been shown to be required for T-cell activation. A familial human immunodeficiency was discovered to be caused by an inactivating mutation in the gene for caspase-8. Taken together, these data allow us to raise the hypothesis that caspases play a permissive role in T lymphocyte physiology presumably by proteolytic processing of a number of cellular proteins, and this will be tested in the project