CORE--NEUROPATHOLOGY

Rush ADCC的神经病理学核心的主要目标是促进阿尔茨海默病的研究 和其他痴呆症，通过向调查人员提供保存完好的脑组织资源，生物 样本，以及神经病理学数据和诊断，来自临床特征良好的老年受试者。完毕 在过去的几年里，核心支持了一系列不同的研究，包括临床病理研究， 轻度认知障碍的研究以及危险因素与神经病理学和神经生物学联系的研究 随着年龄的增长，潜在的认知和运动障碍。此外，核心还将组织分布到 拉什、其他阿尔茨海默病中心的外部资助的调查人员，以及世界各地的其他研究人员 此外，它还为在同行评议期刊上发表大量手稿提供了便利。核心将会 继续为这些研究和出版物提供便利，并在宗教教团研究中招募人员 CORE和临床CORE进一步将这些努力扩展到包括少数族裔受试者和患有非典型肺炎的受试者 痴呆症。神经病理学核心计划继续实施最佳的尸检和收集程序 获取宰前和宰后标本，并继续使用统一、标准和灵活的 保存、加工和储存技术，允许进行不同的研究。核心意志 继续使用对脑组织的最先进的诊断评估来诊断阿尔茨海默病， 脑梗塞、路易体疾病，并将扩大对非典型痴呆症的评估。使用现代的 数据管理系统神经病理核心将索引和存储数据和诊断，使这些 可随时用于外部研究。神经病理核心将继续分发高质量 向外部资助的研究人员提供样本和神经病理数据和诊断，以方便和扩展 阿尔茨海默病和其他痴呆症的研究范围。

The major goal of the Neuropathology core of the Rush ADCC is to facilitate research on Alzheimer's disease and other dementias by providing to investigators a resource of well-preserved brain tissue, biological specimens, and neuropathologic data and diagnoses, from clinically well-characterized older subjects. Over the past years, the Core has supported an array of different studies including clinical-pathologic studies, studies of mild cognitive impairment and studies linking risk factors to the neuropathology and neurobiology underlying cognitive and motor impairment with aging. In addition the core has distributed tissue to externally-funded investigators at Rush, at other Alzheimer's disease centers, and other researchers across the country, and has facilitated the publication of numerous manuscripts in peer-reviewed journals. The core will continue to facilitate these studies and publications and with recruitment in both the Religious Orders Study Core and Clinical Core further extend these efforts to include minority subjects and subjects with atypical dementias. The Neuropathology Core plans to continue to practice optimal autopsy and collection procedures to obtain ante-mortem and post-mortem specimens and continue to use the uniform, standard and flexible techniques for preservation, processing and storage that allow for diverse research studies. The Core will continue to use state of the art diagnostic assessments on brain tissue to diagnose Alzheimer's disease, cerebral infarctions, Lewy body diseases, and will expand assessments for atypical dementias. Using modern data management systems the Neuropathology Core will index and store data and diagnoses making these readily available for external research. The Neuropathology Core will continue to distribute high quality specimens and neuropathologic data and diagnoses to externally funded investigators to facilitate and expand the scope of research on Alzheimer's disease and other dementias.