TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 毫无疑问，获得性免疫缺陷综合征（艾滋病）患者中神经系统的比例很高。 据估计，至少50%，可能高达90%的患者将经历外周（PNS）或中枢神经系统（CNS）功能障碍的一些表现。 1998年，美国国立卫生研究院资助国家神经艾滋病组织联盟在全国范围内开发和维护知识库，并促进中枢神经系统功能障碍领域的研究。总体目标是提供一个关键的资源，这将有助于世界各地的研究人员在阐明机制与艾滋病患者的神经精神问题。 其目标是：1）在受试者死亡之前获得相关的临床、实验室和历史信息; 2）使用统一的协议评估受试者在客观神经精神评估方面的表现; 3）客观地记录每个受试者的药物使用历史; 4）在受试者死亡时获得适当的尸检授权; 5）使用严格定义的脑标本收集和处理机制提供出色的尸检服务; 6）维护一个安全的数据库管理机制，以匿名方式向研究人员提供相关信息; 7）维护一个最先进的样本库设施，在储存、运输和分发给研究界期间，仔细定义生物危害控制和样本保存。这是一项观察性纵向研究，根据健康状况每6个月至2年对受试者进行一次评价。这项研究将组织样本分发给世界各地的研究人员，并提供对研究对象前瞻性收集的测试数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is no doubt that the nervous system is targeted in a high proportion of patients with acquired immunodeficiency syndrome (AIDS). Estimates are that at least 50% and possibly up to 90% of the patients will experience some manifestations of peripheral (PNS) or central nervous system (CNS) dysfunction. In 1998, the National Institutes of Health funded the National NeuroAIDS Tissue Consortium to develop and maintain repositories around the country and promote research in the area of CNS dysfunction. The overarching objective is to provide a critical resource that will assist researchers around the world in elucidating mechanisms involved with neuropsychiatric problems in patients with AIDS. The aims are : 1) obtain pertinent clinical, laboratory and historical information prior to the subject's demise; 2) assess the subject's performance on objective neuropsychiatric assessments using uniform protocols; 3) objectively document each subject's drug use histories; 4) obtain proper authorization for autopsy at the subject's demise; 5) provide excellent autopsy services using rigidly-defined mechanisms for brain specimen collection and handling; 6) maintain a secure mechanism of database management to provide pertinent information anonymously to investigators; 7) maintain a state-of-the-art specimen banking facility with carefully defined biohazard containment and specimen preservation during storage, transport, and distribution to the research community. This is an observational longitudinal study with subjects evaluated every 6 months to 2 years depending on health status. This research distributes tissue samples to researchers around the world and also makes available testing data collected prospectively on research subjects.