ANTERIOR PITUITARY HORMONE REPLACEMENT IN TRAUMATIC BRAIN INJURY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 创伤是一个公认的原因垂体功能减退。15%至20%的成年人谁遭受创伤性脑损伤（TBI），需要住院治疗和康复已被发现有生长激素（GH）缺乏通过GH刺激测试。 此外，还发现皮质醇和甲状腺轴异常。 这一建议的假设是，激素替代治疗在GH，甲状腺或皮质醇轴记录异常的TBI患者将改善肌肉功能，身体成分，有氧能力（GH）和神经心理功能（GH，甲状腺，皮质醇）测试的性能。本研究的目的是：1）确定甲状腺激素替代治疗对TBI受试者神经心理功能的影响，2）确定皮质醇替代治疗对TBI受试者神经心理功能的影响，3）确定重组人生长激素（rhGH）对TBI受试者肌肉功能、身体成分、有氧能力和神经心理功能的影响。研究地点将包括U.T.M.B.的综合临床研究中心。在加尔维斯顿，过渡学习中心（TLC）在加尔维斯顿，并在研究和康复研究所（TIRR）在休斯顿。在加尔维斯顿的GCRC专门进行的活动将包括有氧能力测试、力量测试、身体成分分析和生长激素治疗组的肌肉活检。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Trauma is a well-recognized cause of hypopituitarism. Fifteen to twenty percent of adults who suffer a traumatic brain injury (TBI) that requires hospitalization and rehabilitation have been found to have growth hormone (GH) deficiency by GH stimulation testing. Moreover, abnormalities have also been established for the cortisol and thyroid axis. The hypothesis of this proposal is that hormone replacement in TBI patients with documented abnormalities in the GH, thyroid, or cortisol axis will improve muscle function, body composition, aerobic capacity (GH) and performance in tests of neuropsychologic function (GH, thyroid, cortisol). The Aims of this study are to: 1) determine the effect of thyroid hormone replacement on neuropsychologic function in subjects with TBI, 2) determine the effect of cortisol replacement on neuropsychologic function in subjects with TBI, and 3) determine the effect of recombinant human growth hormone (rhGH) on muscle function, body composition, aerobic capacity, and neuropsychologic function in subjects with TBI. Study sites will include, the General Clinical research center at U.T.M.B. in Galveston, the Transitional Learning Center (TLC) in Galveston, and at The Institute for Research and Rehabilitation (TIRR) in Houston. Activities specifically conducted at the GCRC in Galveston will include aerobic capacity testing, strength testing, body composition analysis, and muscle biopsies on the growth hormone treatment group.