CLINICAL TRIAL: LONG-TERM FOLLOW-UP FOR STUDIES OF GENE TRANSFER (HIV AND OTHERS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该研究旨在为基因转移研究的参与者在每项研究的主动随访阶段后提供长期安全性监测。 重点是载体标记检测的频率、基因转移试验中发生的克隆增殖事件的表征以及存档患者样本以进行进一步的安全性试验。这项研究将为基因转移方法的长期安全性提供深入了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study is designed to provide long-term safety monitoring for participants in gene transfer studies after the active follow-up phase of each individual study. Frequency of vector marking detection, characterization of clonal proliferation events occurring in gene transfer trials as well as archiving patient samples for further safety tests will be the focus. The study will provide insight into the long-term safety of gene transfer approaches.