Clinical Trials Network: Pacific Northwest Node

描述（由申请人提供）：这是太平洋西北（PNW）节点的竞争性更新申请，该节点于2001年1月加入了NIDA国家药物滥用治疗临床试验网络（CTN）。我们的主要目标是继续积极支持CTN的使命，“以科学为载体，提高全国范围内药物滥用治疗的质量”，通过对行为、药理学和综合行为-药理学治疗干预进行严格的研究，多地点临床试验，以确定其在广泛的CTP设置和多样化的患者群体中的有效性，并确保将研究成果转移给治疗提供者。为了有效地实现这些目标，（PNW）节点建议：在研究人员、治疗提供者和政策制定者之间保持有效的双向伙伴关系和工作关系；维持和扩大该节点内高度成功和完善的治疗研究基础设施；通过纳入阿拉斯加的社区治疗项目（CTP）扩大节点的地理覆盖范围，同时扩大节点内的种族多样性；通过增加一个规模更大、研究经验丰富的CTP，加强该节点开展药物治疗试验的能力，并更迅速地对新出现的公共卫生重点作出反应；通过增加一些附属研究人员，拓宽和深化节点的临床研究专业知识，这些研究人员从与CTN直接相关的主题领域的先前干预试验中获得了丰富的经验。在过去的6年里，我们成功地为CTN的使命做出了贡献，并期望在未来继续这样做。从公共卫生的角度来看，作为CTN的一部分，我们在开展此类研究和传播方面继续取得成功，将促进在社区治疗方案中实施有经验支持的、基于证据的干预措施，从而提高药物滥用治疗的质量和有效性。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Pacific Northwest (PNW) Node, which joined the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in January, 2001. Our primary aim is to continue our active support of the CTN's mission, to "improve the quality of drug abuse treatment throughout the country using science as the vehicle" by conducting studies of behavioral, pharmacological, and integrated behavioral-pharmacological treatment interventions in rigorous, multi-site clinical trials to determine their effectiveness across a broad range of CTP settings and diversified patient populations and ensuring the transfer of research results to treatment providers. In order to effectively meet these objectives, the (PNW) Node proposes to: Maintain an effective, bidirectional partnership and working relationship among researchers, treatment providers, and policy makers; Maintain and expand a highly successful and well-established treatment research infrastructure within the Node; Expand the Node's geographical reach by incorporating a community-based treatment program (CTP) from Alaska, also broadening the ethnic diversity within the Node; Enhance the Node's capacity to conduct pharmacotherapy trials and respond more rapidly to emerging public health priorities by adding a larger, highly research-experienced CTP; Broaden and deepen the clinical research expertise of the Node by adding a number of affiliated investigators who bring a wealth of experience from prior intervention trials on topic areas directly relevant to the CTN. We have successfully contributed to the CTN's mission over the past 6 years and anticipate continuing to do so in the future. From a public health perspective, our continued success in conducting such research and dissemination as part of the CTN will facilitate empirically supported, evidence-based interventions being implemented in community-based treatment programs, with a resultant improvement in the quality and effectiveness of substance abuse treatment.