ADMINISTRATIVE AND DATA CORE

行政核心领导制定总体目标和总体研究设计 计划项目赠款(PPG)。核心协调思想、数据、人类主体、组织和 PPG的其他资源。此外，行政核心负责维护PPG 数据库，根据需要提供自定义分析数据集，进行统计分析，并提供 为研究设计和统计分析提供咨询。对于更新，PPG采用了制服 数据集(UDS)，由国家阿尔茨海默病协调中心开发，将促进 向科学界传播研究结果。核心的具体目标有两个方面： 1.行政管理：a)制定PPG的总体科学目标和战略计划，并利用 外部资源，b)组织信息、主题、组织和内部资源的流动 PPG(例如，促进通信、传播信息)，c)确定优先顺序并监测 资源(例如，协调政策、管理预算、审查进展)，d)寻求科学审查和 通过外部咨询委员会提供指导，.e)确保对人类受试者的尊重和安全。 2.统计设计和数据管理：a)提供研究设计和统计分析方面的专门知识，以 核心和项目，b)管理由临床、影像和 神经病理学核心，c)建立和维护研究方案遵守和数据质量的程序 保证，d)编写和提交具体报告(征聘报告、后续行动时间表和监督， 数据质量报告、数据摘要报告、最终神经病理诊断)，e)促进与 科学界。

The Administrative Core leads the development of the overarching goals and overall study design for the program project grant (PPG). The Core coordinates the flow of ideas, data, human subjects, tissues and other resources across the PPG. In addition, the Administrative Core is responsible for maintaining the PPG database, provides custom analytic datasets as needed, conducts statistical analyses, and provides consultation for study design and statistical analyses. For the renewal, the PPG has adopted the Uniform Data Set (UDS), developed by the National Alzheimer Coordinating Center, which will facilitate the dissemination of findings to the scientific community.The specific aims of the Core are two fold: 1. Administrative: a) Develop the overarching scientific goals and strategic plan of the PPG, and leverage outside resources, b) Organize the flow of information, subjects, tissues, and internal resources across the PPG (e.g., facilitate communication, disseminate information), c) Prioritize and monitor the utilization of resources (e.g..coordinate policy, administer the budget, review progress), d) Seek scientific review and guidance via an External Advisory Committee, .e)Ensure respect and safety for human subjects. 2. Statistical design and Data management: a) Provide expertise in study design and statistical analysis to the Cores and Projects, b) manage the PPG database assembled from the Clinical, Imaging, and Neuropathology Cores, c) Institute and maintain procedures for study protocol adherence and data quality assurance, d) Prepare and present specific reports (recruitment reports, follow-up schedules and oversight, data quality reports, data summary reports, final neuropathologic diagnosis), e) Facilitate sharing of data with the scientific community.