CLINICAL RESEARCH SKILLS DEVELOPMENT

人类基因组测序的成功，以及人类健康服务研究的发展，已经 在分子和生理基础的知识基础上产生了一个前所未有的增长时代 人类疾病。大量的高通量基因和基因组技术以及快速的 由计算能力和通信技术的指数增长所决定的信息传播 正在改变临床医学和临床研究的实践。最近发展起来的美国国立卫生研究院 路线图明确了临床研究的重要性，并解决了临床研究的方法 需要转变，以跟上实验室、遗传，特别是基因组研究的步伐，并 确保对调查结果进行测试，并有效地将其转化为卫生和保健方面的改进。这个 这个临床研究技能发展核心(CRSDC)的主要目标是提供一个结构化的、 为医生、内科科学家或科学家培训生提供密集的研究经验，以培养 发展在研究性临床研究中追求成功职业生涯所需的技能 慢性阻塞性肺疾病(COPD)。我们将利用多学科方法，重点放在 人类慢性阻塞性肺疾病的功能基因组学。此处描述的CRSDC通过提供 初级调查人员综合培训方案。在遵守本核心的指导方针下，我们将 包括博士后研究员或初级教员的受训人员，直至他们的K奖培训期。 该委员会有以下具体目标： 具体目标1：提供将临床研究技能与实践相结合的核心课程 利用匹兹堡大学现有的项目进行基因组学和生物信息学培训。 具体目标2：建立一个跨学科的指导系统，使初级调查员 培养他们的研究技能，成为独立而富有成效的临床研究人员。

The successful sequencing of the human genome, and the evolution of human health services research, has produced an era of unprecedented growth in the knowledge base of the molecular and physiological basis of human diseases. The abundance of high throughput genetic and genomic technologies and the rapid spread of information dictated by exponential increase in computing power and communication technology are transforming the practice of clinical medicine and clinical research. The recently developed NIH Roadmap makes clear the importance of clinical research and addresses the ways in which clinical research needs to be transformed to keep pace with laboratory, genetic, and especially genomic research and to ensure that findings are tested and effectively translated into improvements in health and health care. The main objective of this Clinical Research Skills Development Core (CRSDC) is to provide a structured, intensive research experience for physicians, physician-scientists, or scientists trainees to foster the development of skills needed to pursue a successful career in investigative clinical research in the study of chronic obstructive lung disease (COPD). We will utilize a multidisciplinary approach, focusing on the functional genomics of human COPD. CRSDC described here addresses this challenge by providing an integrated training program for junior investigators. In keeping within the guidelines of this Core, we will include trainees at postdoctoral fellow or junior faculty up to their K award training period. The CRSDC has the following specific aims: Specific Aim 1: To offer a core curriculum that integrates clinical research skills with hands-on genomics and bioinformatics training using existing programs at the University of Pittsburgh. Specific Aim 2: To develop a cross-disciplinary mentoring system that will allow junior investigators to develop their research skills and to become independent and productive clinical investigators.