INFANT PRIMATE RESEARCH LAB (IPRL)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的赠款年，IPRL取得了一些值得注意的科学和技术成就。胚胎干细胞(ESC)系由两种猕猴培育而成。到目前为止，已经建立了15个以上的单个细胞系，这些细胞系中处于不同培养阶段的750多个样本已经被超低温保存。来自分裂胚胎的胚胎干细胞系也已被培育出来。IPRL在过去一年的主要努力之一是继续开发使用计算机化触摸屏测试系统的认知测试。在IPRL开发的系统可以成功地用于90天大的婴儿。为了实现为研究人员提供创新测试方法的目标，我们成功地与儿童医院和地区医学中心以及耳鼻喉科的研究人员团队(Jim Phillips博士和Avery Weiss博士)合作开发了测试程序，以研究婴儿灵长类动物的动眼功能发展。IPRL现在可以为研究人员提供幼猴视动和顺畅追踪眼动数据的纵向收集。用于跟踪眼球运动的新测试设备已经捐赠给IPRL，目前正在组装中。儿童地区医院和医疗中心使用相同的刺激和监测工具来收集人类婴儿的数据。我们的数据收集和管理计划的升级仍在继续，所有神经行为数据现在都通过戴尔笔记本电脑和/或掌上设备(如Palm Pilots)收集。我们继续拥有一个欣欣向荣的繁育群体，为实验室开展的项目培育出健康的、妊娠期已知的婴儿。最后，Burbacher、Sackett和Grant博士出版了一本名为《儿童健康和发育障碍的灵长类模型》(Elsevier，2008)的书，强调了灵长类模型在当代儿科研究中的优势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past grant year, there have been a number of notable scientific and technological achievements in the IPRL. Embryonic stem cell (ESC) lines were developed from two species of macaque monkeys. To date, more than 15 individual cell lines have been created and more than 750 samples of these lines at various stages of culture have been cryopreserved. ESC lines from split embryos have also been developed. One of the major efforts in the IPRL during the last year has been to continue developing cognitive tests using a computerized touch-screen testing system. The system developed at the IPRL can be successfully used with infants as young as 90-days of age. To meet our goal of providing investigators with innovative test methods, we have successfully worked with a team of investigators from Children's Hospital and Regional Medical Center and the Dept of Otolaryngology (Drs. Jim Phillips and Avery Weiss) to develop test procedures to study the development of oculomotor function in infant primates. The IPRL can now offer the longitudinal collection of optokinetic and smooth pursuit eye movement data in infant monkeys to investigators. New test equipment to track eye movements has been donated to the IPRL and is currently being assembled. Identical stimuli and monitoring tools are used at Children's Regional Hospital and Medical Center to collect data on human infants. Upgrades of our data collection and management programs have continued and all neurobehavioral data are now collected via DELL laptops and or/hand-held devices such as Palm Pilots. We continue to have a thriving breeding colony to produce healthy, gestation-known infants for projects conducted in the lab. Lastly, Drs. Burbacher, Sackett and Grant published a book titled "Primate Models of Children's Health and Developmental Disabilities" (Elsevier, 2008) to highlight the strengths of the primate model in contemporary pediatric research.