Methodology Core

拟建的加州大学旧金山分校多学科临床研究中心的方法核心单位 将作为MCRC所有项目和活动的枢纽。MCRC方法论核心的主要目标 该单位将在现有基础上，在加州大学旧金山分校推进风湿性疾病后果的临床研究 通过MAMDC和其他外部资金开发的结构。《公约》的具体目标 方法核心是：为MCRC项目提供方法学和生物统计学支持和监督 和使用MCRC数据源的其他项目；协调数据收集和管理用于 《儿童权利公约》项目和研究基地，包括制定议定书、培训工作人员和进行监测， 访谈等数据收集、数据管理、数据分析和质量控制；发挥积极作用 在与风湿病相关的主题方面对研究员和初级教员的教育作用；并推动 加州大学旧金山分校的风湿学知识库和临床研究方法学 在全国范围内，通过外联和传播努力。 方法论核心将服务于MCRC的四个完整项目和一个D&F项目，以及 MCRC和加州大学旧金山分校的研究基地作为一个整体。该股将向MCRC提供服务。 通过指导研究设计、方案和仪器开发、数据管理和 统计分析。以下所述的两个研究项目也将在方法论中进行 核心，这两个项目都将为MCRC项目和研究基地服务。对于使用主数据库的项目 数据来源，方法核心还将处理诸如培训和培训等数据支持服务 对面试人员的监督。方法学核心将积极推动跨学科临床 通过方法学核心教员与研究员一对一会议在MCRC研究基地进行研究 和初级教员，并通过方法论核心教员参与诸如 风湿病杂志俱乐部、医学部临床费尔乔斯计划和加州大学旧金山分校研究所 参加卫生政策研究的博士后奖学金项目。最后，方法论核心股将为 加州大学旧金山分校研究社区，通过赞助季度系列讲座和方法论 核心教员为其他几个长期项目提供咨询服务，包括 哮喘、慢性阻塞性肺病、不孕症和原发性干燥综合征。 方法核心将协调两个主要数据源的数据收集，即狼疮结果 研究(LOS)和类风湿性关节炎小组研究(RA小组)。这两项都是纵向研究，将 在MCRC项目中使用。

The Methodology Core Unit of the proposed UCSF Multidisciplinary Clinical Research Center (MCRC) will serve as the hub for all MCRC projects and activities. The primary goal of the MCRC Methodology Core Unit is to advance clinical research at UCSF in outcomes of rheumatic conditions, building upon the existing structure developed through the MAMDC and other extramural funding. The specific aims of the Methodology Core are to: provide methodological and biostatistical support and oversight to MCRC projects and other projects using MCRC data sources; coordinate data collection and management of data used for MCRC projects and the research base, including protocol development, staff training and monitoring, interviewing and other data collection, data management, data analysis, and quality control; play an active role in education of fellows and junior faculty in topics related to rheumatic disease; and advance the knowledge base in rheumatology and clinical research methodology both on the UCSF campus and nationally through outreach and dissemination efforts. The Methodology core will serve the four full projects and one D&F project of the MCRC, as well as the research base of the MCRC and the UCSF campus as a whole. The unit will provide service to the MCRC projects by guiding all aspects of study design, protocol and instrument development, data management and statistical analysis. Two research projects, described below, will also be undertaken in the Methodology Core, as well, both of which will serve the MCRC projects and research base. For the projects using primary data sources, the Methodology Core will additionally handle such data support services as training and supervision of interview staff. The Methodology Core will actively promote cross-disciplinary clinical research in the MCRC research base through one-on-one meetings of Methodology Core faculty with fellows and junior faculty, and through participation of Methodology Core faculty in established forums such as the Rheumatology Journal Club, the Department of Medicine Clinical Feljows program and the UCSF Institute for Health Policy Study's Postdoctoral Fellowship program. Finally, the Methodology Core Unit will serve the UCSF research community through its sponsorship of a quarterly lecture series and through Methodology Core faculty serving in an advisory role to several other longitudinal projects in chronic conditions, including asthma, COPD, infertility, and primary Sjogren's syndrome. The Methodology Core will coordinate data collection for 2 primary data sources, the Lupus outcomes Study (LOS) and the Rheumatoid Arthritis Panel Study (RA Panel). Both are longitudinal studies that will be used in MCRC projects.