ALTERED NMDA RECEPTOR-MEDIATED TRANSMISSION IN PSD-95 DEFICIENT MICE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 原型突触支架PSD-95直接与NMDA受体（NMDAR）和AMPA受体（AMPAR）相关联，并且被认为调节这些受体在突触处的定位和聚集。尽管进行了广泛的体外研究，PSD-95在体内突触NMDAR和AMPAR的功能状态中的作用仍然难以捉摸。本研究的目的是利用PSD-95缺失的小鼠品系研究PSD-95在前额叶皮层突触传递中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prototypic synaptic scaffold PSD-95 associates with NMDA receptors (NMDARs) directly and AMPA receptors (AMPARs) indirectly, and is thought to regulate the localization and clustering of these receptors at the synapse. Despite extensive in vitro studies, the role of PSD-95 in the functional states of synaptic NMDARs and AMPARs in vivo remains elusive. The purpose of this project is to study the role of PSD-95 in synaptic transmission in the prefrontal cortex using a mouse strain lacking PSD-95.