FOOD-BORNE ANTHRAX THREAT ASSESSMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 炭疽是一种革兰氏阳性芽胞形成细菌，可感染人类和动物。当个人接触受感染动物的材料或吸入与动物产品相关的孢子时，就会发生自然的人类感染。感染可通过三种形式发生：皮肤、吸入和胃肠道。如果不治疗，所有形式的疾病都可能导致死亡。这种疾病最致命的形式是吸入性炭疽病，表现为喉咙痛、轻度发烧、肌肉疼痛和身体不适。即使在包括使用抗生素在内的护理下，死亡率也约为50%。关于胃肠道炭疽病死亡率的信息要少得多。该项目的最终目标是确定非人类灵长类动物疾病的发病机制，并评估氟喹诺酮类药物在预防致命疾病方面的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anthrax is a gram-positive spore forming bacteria that infects both humans and animals. Natural human infections occur when individuals handle materials from infected animals or inhale spores associated with animal products. Infection can occur in three forms: cutaneous, inhalation and gastrointestinal. If left untreated, all forms of the disease could result in death. The most fatal form of the disease, inhalation anthrax, presents with sore throat, mild fever, muscle aches and malaise. The mortality rate is approximately 50% even with care that includes the use of antibiotics. Much less information is known about the mortality of GI anthrax. The ultimate goal for this project is to characterize pathogenesis of disease in nonhuman primates and to assess effectiveness of fluoroquinolone treatment in protecting against lethal disease.