CLINICAL TRIAL: EXPLORATORY PROTEOMIC ANALYSES OF GINGIVAL CREVICULAR FLUID IN H

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：这项研究的总体目的是确定牙周病(牙龈炎)的生物标志物，这些标志物可以在牙周液(牙龈沟液)或唾液中识别，可以用来确定谁患牙周病的风险最高，谁对治疗反应最好。 参赛者：24至30名参赛者，为确保完成24名参赛者，将通过广告招聘。参与者的年龄在18岁到65岁之间，身体健康状况良好，会表现出自然发生的(菌斑引起的)牙周炎，但没有牙周炎的证据。 程序(方法)：这项研究将包括在健康志愿者中诱导实验性牙周炎。参与者将在为期九周的时间内在研究中心停留12个小时(8次访问)。在为期一周的标准卫生阶段之后，参与者将在三周的时间里不在一半的嘴里刷牙和用牙线清洁牙齿，通过放置丙烯酸支架来避免卫生阶段。此后，参与者将恢复正常的全口口腔卫生，每天控制菌斑，并将在牙周炎消退期间接受为期四周的跟踪。如有需要，应在出口处进行刮治和牙根平整预防。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The overall purpose of this research is to identify biological markers for gum disease (gingivitis), which can be identified within the gum fluid (gingival crevicular fluid) or the saliva, that may be used to identify who is at greatest risk for developing gum disease and who responds best to treatments. Participants: Twenty-four to thirty participants, to ensure completion of twenty-four, will be recruited by advertisement. Participants will be between the ages of 18 & 65, will be in good general health and will exhibit naturally occurring (plaque-induced) gingivitis but no evidence of periodontitis. Procedures (methods): This study will involve induction of experimental gingivitis in healthy volunteers. Participants will be seen at the study center for twelve hours (8 visits) over a nine week time period. Following a one-week standard hygiene phase, participants will abstain from brushing and flossing teeth in one half of their mouths during a three week, no hygiene phase via placement of acrylic stents. Thereafter, participants will reinstate normal full mouth oral hygiene, daily plaque control and will be followed for four weeks during gingivitis resolution. Prophylaxis with scaling and root planing will be performed at exit as needed.