ANTECEDENTS OF OBESITY: FETAL MEASURES OF ADIPOSITY (FEMA)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 儿童肥胖及其前驱因素，以及相关的代谢和心血管并发症已被国家儿童研究(NCS)列为研究目标。早期的生长模式与代谢和心血管疾病以及儿童和成人肥胖有关。 本研究的目的是确定二维超声测量胎儿体脂(U/S)是否可以预测新生儿的身体成分。我们将测试以下特定目标：特定目标1：确定二维U/S测量的胎儿脂肪是否可以预测出生时和6周时BIA、DXA和空气置换体积描记仪测量的婴儿脂肪量。特异性目的2：证实IUGR患儿血清胰岛素、IGF-1、IGFBP-1和-3、脂联素和瘦素水平降低，巨大儿升高。特异性目的3：验证滤纸上干血点测得的血清脂联素与脐带或鞋跟粘血测得的血清脂联素的值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Childhood obesity, its antecedents, and associated metabolic and cardiovascular co-morbidities have been targeted by the National Children's Study (NCS) for study. Early growth patterns have been linked to metabolic and cardiovascular diseases and childhood and adult obesity. The purpose of this study is to determine whether fetal body fat measured by 2-D ultrasound (U/S) predicts neonatal body composition. We will test the following specific aims: SPECIFIC AIM 1: To determine whether fetal fat measured by 2-D U/S predicts infant fat mass measured by BIA, DXA, and air displacement plethysmography (ADP) at birth and 6 wks. SPECIFIC AIM 2: To confirm that Infant serum insulin, IGF-1, IGFBP-1 & -3, adiponectin, and leptin values are reduced in IUGR infants and elevated in macrosomic infants. SPECIFIC AIM 3: To validate serum adiponectin values measured from the dry blood spot on filter paper against serum adiponectin values measured from cord or heel stick blood samples.