EARLY DIAGNOSIS OF NOSOCOMIAL CANDIDIASIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目的是： 1)前瞻性评价三种新的新生儿侵袭性念珠菌病诊断方法。 2)建立临床表现的风险约束模型。 3)对照床边临床医生的判断，检验临床模式的性能。 次要目标： 1)确定根据良好临床实践(GCP)进行终末器官损害评估的新生儿的终末器官损害累积发生率。 2)确定从入选患者血液中分离的念珠菌的耐药模式和基因表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Primary Aims of this study are: 1) Prospectively evaluate three new diagnostic tests for invasive neonatal candidiasis. 2) Develop a risk-straification model on clinical presentation. 3) Test the peformance of the clinical model against the judgment of bedside clinicians. Secondary Aims: 1) Determine cumulative incidence for end-organ damage in those neonates who are evaluated for end-organ damage in accordance with Good Clinical Practice (GCP). 2) Determine resistance patterns and gene expression by Candida isolated from the blood of enrolled patients.