CLINICAL TRIAL: INVESTIGATION OF THE NATURAL HISTORY OF WEST NILE VIRUS INFECTIO

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 UNM的医学和神经病学部门正在通过参与NIH赞助的描述疾病自然史和测试新疗法的试验来应对新出现的病毒性疾病西尼罗河病毒。 拟定的研究旨在1）检测WN免疫球蛋白在高危人群中预防或消除重度WN疾病的安全性和有效性（I/II期），2）确定WN感染的自然史。 建议的研究将整合基础科学和临床科学。 病毒特征和免疫反应将在美国大学进行。亚拉巴马和新墨西哥大学。临床研究包括观察性研究和I/II期治疗试验。 教育方面包括指导研究员、住院医生和初级教员，他们将作为新的研究人员参加试验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The divisions of Medicine and Neurology at UNM are responding to an emerging viral disease, West Nile Virus, by participating in NIH sponsored trials describing the natural history of illness and testing a new therapy. The proposed studies aim to 1) test safety and efficacy (phase I/II) of WN immune globulin in preventing or abrogating severe WN disease in high risk population groups, and 2) to define the natural history of WN infection. The proposed studies will integrate basic science and clinicalscience. Virus characterization and immune responses will take place at U. Alabama and at UNM. Clinical studies include an observational study and a Phase I/II treatment trial. Educational aspects include mentoring of fellows, residents and junior faculty who will be participating as new investigators on the trials.