LATE-LIFE DEPRESSION: NEUROBIOLOGICAL AND CLINICAL SUBSTRATES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 严重抑郁症。 研究神经解剖学变化和总体医疗负担（包括脑血管危险因素）在初级保健/老年环境中出现的重度抑郁症发展中的作用。 我们研究的主要目的是将神经解剖学信息与临床和行为测量相结合，以获得对晚年MDD神经生物学基础的更全面的了解。 除了形态测量外，我们还建议扩展我们的MR方法，包括质子MR波谱（MRS），以检查相关的生化指标，如N-乙酰-L-天冬氨酸、胆碱、乳酸和肌肌醇（mI）。 总的来说，这些神经解剖学，生化和临床措施，将提供更广泛的见解生物畸变，导致抑郁症的晚年生活。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MAJOR DEPRESSION. To examine the role of neuroanatomical changes and overall medical burden including cerebrovascular risk factors, in the development of major depression presenting at primary care/geriatric settings. A principal objective of our study is to integrate the neuroanatomical information with clincal and behavioral measures in order to obtain a more holistic picture of the neurobiologic basis of late-life MDD. In addition to morphometry, we propose to expand our MR approaches to include proton MR Spectroscopy (MRS), to examine revlevant biochemical measures such as N-Acetyl-L-Aspartate, Choline, Lecithin and myo-inosital (mI). Collectively these neuroanatomical, biochemical and clinical measures, will provide broader insights into the biological aberrations that lead to depression in late-life MDD.