CRANBERRY JUICE-CEFACLOR INTERACTION IN HEALTHY WOMEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 蔓越莓汁已被广泛用于预防和治疗尿路感染（UTI）的替代疗法，尽管其疗效的证据有限。 在UTI抗生素治疗期间同时使用蔓越莓汁是非常常见的，特别是对于那些经历复发性UTI感染的人。 然而到目前为止，关于药物与蔓越莓产品相互作用的信息很少。因此，确定β-内酰胺抗生素和蔓越莓汁之间的潜在不良药物相互作用是至关重要的，因为它作为UTI预防和治疗的非抗生素替代品具有巨大的公共卫生潜力。最近的几项研究表明，果汁可能会影响膜转运蛋白的活性，这对抗生素的吸收和消除至关重要。根据药物-果汁相互作用的临床报告，我们提出，蔓越莓汁成分或其全身代谢产生的副产物可能会干扰载体介导的肠道吸收和/或β-内酰胺类抗生素与抗生素联合给药时的肾排泄。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cranberry juice has been widely used in the prevention and treatment of urinary tract infections (UTI) as alternative therapy in spite of limited evidence of its efficacy. Concurrent use of cranberry juice during UTI antibiotic therapy is very common, especially for those who experience recurrent UTI infections. However up to date, little information is available regarding drug interactions with cranberry products. Thus identifying potentially adverse drug interactions between beta-lactam antibiotics and cranberry juice are of paramount importance given its great public health potential as a non-antibiotic alternative in UTIs prophylaxis and treatment. Several recent studies have shown that fruit juices may affect activities of membrane transporters which are important in the absorption and elimination of antibiotics. In light of clinical reports of drug-fruit juice interactions, we propose that cranberry juice ingredients or its byproducts arising from systemic metabolism may interfere with carrier-mediated intestinal absorption and/or renal excretion of beta-lactam antibiotics when it is co-administered with the antibiotics.