The District of Columbia Developmental Center for AIDS Research (DC D-CFAR)

描述(由申请人提供)：此申请表描述了我们关于建立哥伦比亚特区艾滋病研究发展中心(DC D-CFAR)的建议。尽管疫情在我国首都严重，但华盛顿特区从未出现过由NIH资助的CFAR。华盛顿特区的D-CFAR将是艾滋病毒/艾滋病研究所的产物，该研究所成立于2006年，代表了华盛顿特区艾滋病毒/艾滋病研究、临床护理和教育领域的80多名教职员工。该研究所在艾滋病毒/艾滋病研究、教育和服务活动方面建立了强大的基础，这将成为大大扩大DC-CFAR活动组合的基础。华盛顿特区D-CFAR的目标是：1)领导华盛顿特区的艾滋病毒/艾滋病研究；2)促进华盛顿特区初级、少数民族和新的艾滋病毒/艾滋病研究人员的发展；3)通过资金、专业网络和科学领导，加强华盛顿特区艾滋病毒/艾滋病调查人员之间的联系和合作。华盛顿特区D-CFAR将解决国家CFAR计划的总体任务和目标，重点是华盛顿特区疫情的独特方面，以及当地学术机构和调查人员的优势。参加华盛顿特区D-CFAR的机构有：国家儿童医学中心；乔治敦大学；乔治华盛顿大学公共卫生和卫生服务学院(SPHHS)、医学和健康科学学院、哥伦比亚艺术与科学学院；霍华德大学；以及退伍军人事务医学中心。执行委员会包括来自这些机构的主要艾滋病毒/艾滋病调查员。两个主要的社区艾滋病毒/艾滋病护理提供者，惠特曼·沃克诊所和联合健康护理公司，也同意参加华盛顿特区的D-CFAR。GW SPHSS流行病学和生物统计学系主任兼艾滋病毒/艾滋病研究所联席主任Alan Greenberg博士是拟议的DC D-CFAR的首席调查员。DC D-CFAR将有五个核心--核心A行政、核心B发展、核心C临床、核心D基础科学和核心E公共卫生和政策。DC D-CFAR将包括三个咨询委员会：由每个合作的DC机构的高级领导组成的监督委员会；由其他CFAR的核心主任组成的科学咨询委员会；以及由华盛顿特区主要的艾滋病毒/艾滋病社区组织领导的社区咨询委员会。如所附的支持信所示，哥伦比亚特区D-CFAR得到了哥伦比亚特区领导(市长、卫生局局长和艾滋病毒/艾滋病管理局高级副局长)、主要社区组织和每个合作机构的大力支持。 核心A： 标题：-行政核心 项目负责人：格林伯格，A. 核心A描述(由申请人提供)：行政核心将领导和管理哥伦比亚特区艾滋病研究发展中心(“DC D-CFAR”)，以解决国家CFAR计划的总体任务和目标，重点放在DC D-CFAR的独特方面--解决华盛顿特区严重的艾滋病毒/艾滋病流行；发展研究人员的艾滋病毒/艾滋病研究能力，重点是来自美国首都主要学术机构的初级和少数族裔研究人员；以及利用艾滋病毒/艾滋病研究所的现有基础设施和计划。行政核心的具体目标包括：1.领导和管理DC D-CFAR 2.促进多学科和多机构的艾滋病毒/艾滋病科学研究和教育活动3.确保负责任地监督和管理DC D-CFAR的所有财政和人力资源4.确保DC D-CFAR科学和教育活动的质量不断提高行政核心将为发展和三个科学核心在促进和交付与艾滋病毒/艾滋病有关的研究方面有效发挥作用提供必要的领导和基础设施。在接到供资通知后，行政核心将立即协助向DC DCFAR过渡。在整个过渡期间，将采取必要的步骤来实施财政机制，使我们的多机构D-CFAR能够发挥作用；将奖励资金和过渡计划通知所有核心董事和咨询委员会成员；并与所有成员、潜在的核心用户和其他关键利益相关者沟通华盛顿特区D-CFAR的机构。此后，行政核心将通过持续的会议、教育研讨会、沟通机制、赠款管理、财政监督以及监测和评价活动，继续监督和管理DC D-CFAR的运作，这将使DC D-CFAR能够继续发展，因为它为今后成为一个全面的CFAR奠定了必要的基础。

DESCRIPTION (provided by applicant): This application describes our proposal to establish the District of Columbia Developmental Center for AIDS Research ("DC D-CFAR"). Despite the severity of the epidemic in our nation's capital, there has never been a NIH-funded CFAR in Washington DC. The DC D-CFAR would be an outgrowth of the HIV/AIDS Institute, an organization founded in 2006 which represents more than 80 faculty members working in HIV/AIDS research, clinical care and education in Washington DC. The Institute has built a strong base of HIV/AIDS research, educational and service activities which would serve as the foundation for a greatly expanded portfolio of DC D-CFAR activities. The Aims of the DC D-CFAR are to 1) Provide leadership to advance HIV/AIDS research in Washington DC; 2) Promote the development of junior, minority, and new HIV/AIDS investigators in Washington DC; and 3) Increase connectivity and collaboration among HIV/AIDS investigators in Washington DC through funding, professional networking, and scientific leadership. The DC D-CFAR would address the overall mission and goals of the national CFAR Program, with a focus on the unique aspects of the epidemic in Washington DC, and on the strengths of local academic institutions and investigators. The institutions participating in the DC D-CFAR are the Children's National Medical Center; Georgetown University; George Washington University (GW) School of Public Health and Health Services (SPHHS), School of Medicine and Health Sciences, and Columbian College of Arts and Sciences; Howard University; and the Veterans Affairs Medical Center. The Executive Committee includes leading HIV/AIDS investigators from each of these institutions. Two major community-based HIV/AIDS care providers, the Whitman Walker Clinic and Unity Health Care, have also agreed to participate in the DC D-CFAR. Dr Alan Greenberg, Chair of the GW SPHSS Department of Epidemiology and Biostatistics, and Co-Director of the HIV/AIDS Institute, is the Principal Investigator of the proposed DC D-CFAR. The DC D-CFAR would have five Cores - Core A Administrative, Core B Developmental, Core C Clinical, Core D Basic Science, and Core E Public Health and Policy. The DC D-CFAR will include three Advisory Committees: the Oversight Committee with senior leadership from each of the collaborating DC institutions; the Scientific Advisory Committee composed of Core Directors from other CFARs; and the Community Advisory Board with the leadership of the major HIV/AIDS community-based organizations in Washington DC. As reflected in the accompanying letters of support, the DC D-CFAR has received strong support from the leadership of the District of Columbia (Mayor, Department of Health Director, and HIV/AIDS Administration Senior Deputy Director), from major community-based organizations, and from each of the collaborating institutions. CORE A: Title: - Administrative Core Project Leader: Greenberg, A. CORE A DESCRIPTION (provided by applicant): The Administrative Core will lead and govern the District of Columbia Developmental Center for AIDS Research (the "DC D-CFAR") to address the overall mission and goals of the national CFAR Program, with a focus on the unique aspects of the DC D-CFAR - addressing the severe HIV/AIDS epidemic in Washington DC; developing HIV/AIDS research capacity among investigators, with a focus on junior and minority investigators, from the major academic institutions in the nation's capital; and capitalizing on the existing infrastructure and programs of the HIV/AIDS Institute. The specific aims of the Administrative Core include the following: 1. Provide leadership and governance of the DC D-CFAR 2. Promote multidisciplinary and multi-institutional scientific HIV/AIDS research and educational activities 3. Ensure the responsible oversight and management of all DC D-CFAR fiscal and personnel resources 4. Ensure the continuous quality improvement of DC D-CFAR scientific and educational activities The Administrative Core will provide the leadership and infrastructure necessary for the Developmental and three Scientific Cores to function effectively in their promotion and delivery of research related to HIV/AIDS. Upon notification of funding, the Administrative Core would immediately facilitate the transition to a DC DCFAR. Throughout this transition the necessary steps would be taken to implement the fiscal mechanisms that will allow our multi-institutional D-CFAR to function; notify all Core Directors and Advisory Committee members about the award funding and the transition plan; and communicate with all members, potential Core users and other key stakeholders about the institution of the D-CFAR in Washington DC. Thereafter, the Administrative Core would continue to provide oversight and to manage the functioning of the DC D-CFAR through ongoing meetings, educational seminars, communication mechanisms, grant management, fiscal oversight and monitoring and evaluation activities that would allow for the continual growth of the DC D-CFAR as it builds the foundation necessary to function as a full CFAR in the future.