Molecular mechanisms underlying induction of Haematopoietic Stem cells in the embryo

造血，即制造血细胞的过程，是研究干细胞生物学的最佳范例之一，但我们对这些细胞在胚胎中如何形成的理解尚不完整。我们的初步研究已经揭示了一种新的“伙伴细胞”的存在，它直接调节血液干细胞的诱导。这项拨款旨在进一步研究这些观察结果，其总体目标是确定伙伴细胞用来制造血液干细胞的分子信号

Hematopoiesis, the processes of making blood cells, represents one of the best-defined paradigms for studying stem cell biology, but our understanding of how theses cells form in the embryo is incomplete.Our preliminary studies have revealed the existence of a novel "buddy cell" that directly regulates the induction of blood stem cells. This grant seeks to further these observations, and its general aim is to identify the molecular signals that the buddy cell uses to make blood stem cells