OPERATION AND MAINTENANCE OF A PROTEIN DATABASE SEARCH SERVER

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 带有吉祥物软件的服务器被用于许多研究和合作项目的多肽和蛋白质序列分析。例如，我们用LC-MS/MS分析多肽混合物或消化的蛋白质，并提交光谱进行分析，以确定抗原肽的序列和蛋白质来源，并用于肌肉蛋白质组计划。了解抗原的性质有助于对抗糖尿病等自身免疫性疾病。 这些服务器还被用于许多其他项目，包括HDX和蛋白质足印等核心项目，肌肉等待和阿尔茨海默病的合作项目，以及蛋白质识别服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Servers with MASCOT software are used to analyze peptide and protein sequences for many reaserch and collaborative projects. For example we analyze peptide mixtures or digested proteins by LC-MS/MS and submit the spectra for analysis to determine the sequences and protein origin of antigenic peptides and for the muscle proteom project. Knowledge of the nature of antigens can help fight autoimmune diseases like diabetes. The servers are being used for many other projects that include core projects like HDX and foot printing of proteins, collaborative projects on muscle waisiting and Alzhiemer disease and service for protein identifications.