Cross Region Neural Computation Subserving Attention

注意力在我们的意识体验中是非常关键的。注意力不集中或不能转移注意力可能是 毁灭性的，并可能导致神经和精神疾病，如注意力缺陷 多动症(ADHD)、阅读障碍和精神分裂症。来自Desimone实验室和其他实验室的实验 已经表明，注意力改变了许多视觉区域的神经活动，并使整个大脑的活动同步 地区。越来越多的证据表明，存在自上而下的调节机制 请注意。然而，这些效应背后的精确神经回路在很大程度上是未知的，而且它仍然存在。 难以建立特定神经回路或细胞类型活动之间的因果联系，并出现 行为和病理。因此，我将开发使用激活和 以毫秒级的精度使特定类型的神经元静音，以执行时间解析 特定的前额神经活动模式在调节自上而下中的必要性和充分性分析 控制注意力。

Attention is highly critical tp our conscious experience. A failure to focus or to shift attention can be devastating, and may contribute to neurological and psychiatric diseases such as attention deficit hyperactivity disorder (ADHD), dyslexia, and schizophrenia. Experiments from the Desimone lab and others have shown that attention alters neural activity in many visual areas and synchronizes activity across brain regions. There is increasing evidence for the presence of top-down modulatory mechanisms mediating attention. However, the precise neural circuitry underlying these effects is largely unl<nown, and it remains difficult to establish causal linl<s between activities in specific neural circuits or cell types, and emergent behaviors and pathologies. Accordingly, I will develop the use ofthe technologies for activating and silencing specific types of neurons with millisecond-timescale precision, with which to perform a timeresolved analysis of necessity and sufficiency of specific prefrontal neural activity patterns in mediating topdown control of attention.