NRAMM Biennial Workshop on Advanced Topics in EM Structure Determination

描述(由申请者提供)：我们正在申请资金，以部分支持将于2012年11月和2014年11月由国家自动化分子显微镜资源主办的两年一次的研讨会。这一持续的讲习班建立在一个成熟和非常成功的系列(2003年11月、2005年11月、2007年11月、2009年11月)的基础上，该系列对使用分子显微镜作为结构技术的科学家群体产生了很大影响。研讨会的主要目标是提供一个场所，集中讨论分子显微镜领域面临的最紧迫的技术挑战。研讨会汇集了资深思想领袖、追求新方法的新研究人员、博士后研究员、研究生、其他领域的知名研究人员、行业合作伙伴和其他感兴趣的各方，在一周的密集学习、互动和讨论中。讲习班演示文稿以幻灯片和音频文件的形式通过网站向一般社区传播，这大大增加了讲习班的影响，超过一周的时间和约140名参与者。 公共卫生相关性(由申请人提供)：电子显微镜(EM)现在被确立为研究对细胞功能至关重要的大分子机器的基本工具，因此对健康和疾病状态都具有基本和基本的相关性。这次研讨会的重点是讨论仍然限制该方法充分发挥其潜力的挑战，在教学和推动整个领域向前发展方面都发挥着独特的作用。

DESCRIPTION (provided by applicant): We are requesting funds in partial support of a biennial workshop to be hosted by the National Resource for Automated Molecular Microscopy, in November 2012 and November 2014. This continuing workshop builds on a well-established and very successful series (held in November 2003, 2005, 2007, 2009) that has had a high impact on the community of scientists using molecular microcopy as a structural technique. The primary objective of the workshop is to provide a venue for focused discussion of the most pressing technical challenges facing the field of molecular microscopy. The workshop brings together senior thought leaders, new investigators pursuing novel approaches, postdoctoral fellows, graduate students, established investigators in others fields, industrial partners, and other interested parties, in an intensive week of learning, interaction and discussion. The workshop presentations, in the form of slides and audio files, are disseminated via a web site to the general community, which substantially increases the impact of the workshop beyond the one week duration and the ~140 participants. PUBLIC HEALTH RELEVANCE (provided by applicant): Electron microscopy (EM) is now established as an essential tool for studying macromolecular machines that are central to cellular function, and thus has a basic and fundamental relevance for both the healthy and diseased states. This workshop, which is focused on discussing the challenges that still limit the method from reaching its full potential, serves a unique role, both pedagogically and in moving the entire field forward.