2010 Biology of Aging Gordon Research Conference and/or Gordon Research Seminar

描述(由申请人提供)：戈登衰老生物学研究会议(GRC)自1962年以来每18个月举行一次，是GRC将于2010年组织的170多个会议的一部分，GRC是一个因其会议的高质量和尖端性质而闻名世界的组织。本申请中描述的2010年老龄化生物学全球研究中心的项目是围绕“健康的决定因素--跨度：从细胞到人类”这一主题开发的，它将作为讨论最近出现的感知、测量和研究老龄化的方式变化的基础。衰老是一个多因素的复杂过程，是遗传、生化和生理水平变化的结果。近年来，我们对衰老和衰老相关疾病的细胞和动物模型的这些变化的理解取得了惊人的进展。该领域目前的挑战有两个：1)继续并完成对导致老龄化的因素的分子剖析；2)促进将这些新发现转化为干预措施，以改善我们老龄化人口的健康寿命。本次戈登研究会议将汇聚对老龄化生物学的不同方面具有广泛兴趣的领先国际专家，并将创建一个高质量的科学论坛，讨论老龄化基本机制的研究结果，并将其落实到旨在提高老龄化人口健康质量的干预措施中。此外，在本次会议的历史上，将第一次由初级研究人员(学生和博士后级别)组织会议前戈登研究研讨会。研讨会期间的活动完全面向初级研究人员，目的是1)为他们提供必要的衰老生物学的基本背景，以最大限度地了解会议中讨论的科学；2)从该领域的专家那里获得对他们正在进行的研究项目的反馈；3)促进他们与该科学界的高级成员的互动，并促进年轻一代老年研究人员之间的联系。意义：我们充分预期，本次会议与会者之间的科学讨论、研究会谈和非正式互动将有助于增进我们对与衰老相关的功能衰退背后的分子机制的理解，并将为旨在促进人类健康老龄化的协作干预措施的发展奠定基础。 与公共健康相关：戈登老龄生物学研究会议将汇集不同基础科学学科(生物化学、细胞生物学、遗传学等)的主要领导者。以及与老年学相关的临床领域(神经病理学、内分泌学、新陈代谢专家等)以及初级研究人员，这将构成对老龄化领域感兴趣的下一代研究人员，他们还将参加会前戈登研究研讨会。本次会议期间的科学陈述、讨论和研讨会将有助于我们加深对老年人功能衰退和某些老年人某些疾病发病率增加的原因的理解。预计这次会议传统上的合作和合作氛围将为智力发展和未来实施干预措施提供完美的环境，以确保健康老龄化。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Biology of Aging has been held every 18 months since 1962 and is part of the over 170 conferences that will be organized in 2010 by GRC, an organization known world-wide because of the high-quality cutting-edge nature of its conferences. The program for the 2010 GRC on Biology of Aging described in this application has been developed around the theme "Determinants of Health-span: from cell to humans" which will serve as a basis for discussion of the recently emerging changes in the way in which aging is perceived, measured and studied. Aging is a multifactorial and complex process that results from changes at the genetic, biochemical and physiological level. Our understanding of those changes in cellular and animal models of aging and age-related disorders has advanced vertiginously during recent years. The current challenge of this field is two-fold: 1) to continue and complete the molecular dissection of the factors that contribute to aging and 2) to promote the translation of these novel findings into interventions to improve the health-span of our aging human population. This Gordon Research Conference will bring together leading international experts with a broad range of interests related to diverse aspects of biology of aging, and will create a high quality scientific forum for discussion of findings on the basic mechanisms of aging and their implementation into interventions aimed at increasing quality of heath in the aging population. Furthermore, for the first time in the history of this conference, a pre-conference Gordon Research Seminar will be organized by junior investigators (student and postdoctoral level). The activities during the Seminar are completely oriented to junior investigators and are intended to 1) provide them with the basic background on Biology of Aging necessary to maximize their understanding of the science discussed in the conference, 2) receive feedback on their ongoing research projects from experts in the field and 3) facilitate their interaction with senior members of this scientific community and promote networking in between the junior generation of aging researchers. Significance: We fully anticipate that the scientific discussions, research talks and informal interactions between the participants in this conference will contribute to advance our understanding of the molecular mechanism behind the functional decline associated to aging and will set the basis for the development of collaborative interventions aimed at promoting healthy human aging. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Biology of Aging will bring together major leaders in different basic scientific disciplines (biochemistry, cell biology, genetics, etc.) and in clinical areas of relevance to gerontology (neuropathology, endocrinology, experts in metabolism, etc.) along with junior investigators that will constitute the future generation of researchers with interest in the field of aging and who will participate in addition in the pre-meeting Gordon Research Seminar. The scientific presentations, discussions and workshops during this conference will contribute to advance our understanding of the reasons for the functional decline that occurs in aging individuals and the increased incidence of certain pathologies in elders. It is anticipated that the collegial and cooperative atmosphere that has traditionally characterized this conference will provide the perfect setting for the intellectual development and future implementation of interventions to assure healthy aging.