PERIPARTUM CHANGES IN MONOAMINE ACTIVITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目旨在收集试点数据，以支持对NIH的拨款申请，以更好地了解怀孕期间单胺系统的变化，这些变化可能预测哪些女性更有可能表现出产后抑郁症症状。使用微型PET神经成像，初步研究表明，多巴胺2(D2R)受体结合从怀孕到产后早期发生了变化。由于D2R的差异与抑郁症状有关，这些数据表明，恒河猴模型可以用来显示D2R在抑郁症状中的可塑性 围产期与社会情绪行为的变化有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to develop to collect pilot data in support of a grant application to NIH to better understand how changes in monoamine systems emerge during pregnancy that may predict what females may be more likely to exhibit postpartum depression symptomotology. Using microPET neuroimaging, the pilot study showed that dopamine 2 (D2R) receptor binding changed from pregnancy to the early postpartum interval. Because differences in D2R has been implicated in depressive symptoms these data that a rhesus monkey model can be used to show how D2R plasticity during the peripartum period is associated with socio-emotional behavior changes.