Intestinal Stem Cell Consortium Coordinating Center

描述(申请人提供)：我们将在希望之城建立肠道干细胞联盟协调中心。ISC-CC将由信息科学主席乔伊斯·C·尼兰博士领导。ISCC-CC的总体目标是支持肠干细胞联盟(ISCC)建立高效、有效的程序来保存、分离和鉴定肠道干细胞，同时开发和验证这类细胞的特定标记物。ISCC-CC将通过与NIDDK选择的5-7个不同研究项目的调查人员合作来做到这一点。ISCC-CC将优化ISCC项目的研究管理、协调、质量控制和信息管理。 具体目标是： 1.就所有指导会议和小组委员会会议以及电话会议向国际协调委员会提供行政支助和监督； 2.履行所有ISCC-CC研究项目共同的行政职能，协调集中的ISCC-CC系统和程序最好地开展的ISCC活动； 3.利用最先进的信息技术和强大的安全/保密能力，建立和维持国际合作委员会的信息系统和信息管理程序； 4.通过分配ISCC资源，例如ISCs，以及ISCC成员之间研究进展、方法、数据和信息的数据交换，促进转化性研究；以及 5.支持ISCC实验和数据的设计、分析和质量保证，优化ISCs的生产和共享，开发和验证干细胞标记。 与公共卫生相关：影响小肠的疾病是一种多样化的疾病集合，可导致受影响个人从腹泻到死亡的任何事情。2004年，美国约有236,000人死于消化系统疾病，直接和间接费用近1420亿美元。在这些报告的死亡中，9836人全部可归因于小肠疾病。了解小肠的生物学将有助于开发治疗肠道疾病的疗法。

DESCRIPTION (provided by applicant): We will establish the Intestinal Stem Cell Consortium Coordinating Center (ISCC-CC) at City of Hope. The ISC-CC will be under the direction of Dr. Joyce C. Niland, Chair of Information Sciences. The overall objective of the ISCC-CC is to support the Intestinal Stem Cell Consortium (ISCC) in establishing efficient and effective procedures for the preservation, isolation, and characterization of intestinal stem cells, while developing and validating specific markers for this population of cells. The ISCC-CC will do this by working with investigators from 5-7 different research projects chosen by NIDDK. The ISCC-CC will optimize study administration, coordination, quality control and information management across the ISCC projects. The specific aims are: 1. To provide administrative support and oversight to the ISCC for all Steering and Sub-Committee meetings and teleconference calls; 2. To serve the administrative functions common to all ISCC-CC research projects, coordinating ISCC activities that are best served by centralized ISCC-CC systems and processes; 3. To create and maintain the ISCC information systems and information management processes, using state-of-the-art information technology and robust security/confidentiality; 4. To promote translational research through distribution of ISCC resources, e.g. ISCs, and data exchange of research progress, methods, data, and information between members of the ISCC; and 5. To support the design, analysis and quality assurance of ISCC experiments and data, to optimize the production and sharing of ISCs and develop and validate stem cell markers. PUBLIC HEALTH RELEVANCE: Diseases affecting the small intestine represent a diverse collection of conditions that can cause anything from diarrhea to death in affected individuals. In 2004 digestive diseases were responsible for approximately 236,000 deaths in the United States and nearly $142 billion dollars in direct and indirect expenses. Of those reported deaths, 9836 were attributable, in part of whole, to conditions of the small intestine. Understanding the biology of the small intestine will aid in the development of therapies to treat intestinal diseases.