Cancer Biology Training Grant

描述（由申请人提供）：这个博士前和博士后培训计划强调板凳到床边的研究，包括癌症研究的最先进的领域。沿着在癌症研究和健全的科学理论的基础培训，学生和博士后研究员将在癌症研究的许多基本领域，包括，药物发现使用高通量化学和遗传筛选，以确定细胞网络，信号转导途径，DNA损伤和修复反应，和纳米靶向治疗药物输送使用细胞和动物分子成像。21世纪的癌症问题仍然是国家的优先事项，因此，为博士前和博士后学生的培训提供了实质性的长期职业机会。我们的培训计划的目标是（a）培养能够进行独立的癌症研究的高素质的科学家;（B）培养在当今和未来的学术或工业领域取得成功所需的智力，技术和沟通技能;（c）提供对人类癌症的基本，公共卫生和临床问题的理解。这项培训补助金的能力，以弥合基础科学学院现有的优秀基础与我们的癌症生物学和治疗方案在哈罗德西蒙斯NCI指定癌症中心，区别于标准化的一般研究生和研究生教育计划。我们有43承诺教师培训代表24个不同的部门和中心在UT西南。我们已经召集了一个专门的指导委员会成员小组，沿着行政支持以及癌症中心主任的智力和财政支持。我们为博士前和博士后学员制定了一项综合计划，详细介绍了癌症教育和培训的所有关键步骤，包括生物医学伦理，负责任的科学行为，生物统计学，生物信息学和数据共享。我们有一个具体的计划，用于招聘和保留广泛的地理范围的博士前和博士后申请人以及代表性不足的多元化学员。我们已经扩大和实施了我们的癌症教学和期刊导向的课程，包括基础和翻译。在过去的4年里，我们国内合格的博士前和博士后申请人几乎翻了一番，我们的教师培训师人数增加了约50%。 公共卫生相关性： 此T32更新申请描述了一个全面的招聘，培训和保留计划，该计划将强大的基础科学课程与强大的转化癌症重点相结合，使其有别于其他培训计划。我们的目标是培养能够进行独立癌症研究的高素质科学家;培养在当今和未来的学术或工业领域取得成功所需的智力，技术和沟通技能;并提供对人类癌症的基本，公共卫生和临床问题的理解。在我们的第一次审查期间，50%的所有被任命者都是多样性的受训人员，我们的癌症生物学计划已得到德克萨斯州高等教育委员会的完全批准，UT西南已成为NCI指定的癌症中心，我们增加了我们的癌症相关资金几乎5倍，我们增加了我们的学生和博士后T32合格的受训人员超过3倍。

DESCRIPTION (provided by applicant): This predoctoral and postdoctoral training program emphasizes bench to bedside research encompassing state-of-the-art areas of cancer research. Along with training in the fundamentals of cancer research and sound scientific theory, students and postdoctoral fellows will be trained in many fundamental areas of cancer research including, drug discovery using high throughput chemical and genetic screens to define cellular networks, signal transduction pathways, DNA damage and repair responses, and nanomedicine-targeted therapeutic drug delivery using cell and animal molecular imaging. The problem of cancer in the 21st century remains a national priority, and as such, offers a substantive long-term career opportunity for the training of predoctoral and postdoctoral students. The goals of our training program are to (a) train top-quality scientists capable of conducting independent cancer research; (b) foster the intellectual, technical, and communication skills required to succeed in the academic or industrial arenas of today and in the future; and (c) provide an understanding of the basic, public health, and clinical problems of human cancer. The ability of this training grant to bridge an existing outstanding foundation of Faculty in Basic Science with our Cancer Biology and Therapy Programs in the Harold Simmons NCI Designated Cancer Center, distinguishes it from a standardized general graduate and post-graduate educational program. We have 43 committed Faculty Trainers representing 24 different Departments and Centers at UT Southwestern. We have assembled a dedicated group of Steering Committee members, along with Administrative Support and both intellectual and financial support from the Director of the Cancer Center. We have an integrated plan for the proposed Cancer Training Program for both predoctoral and postdoctoral trainees that details all key steps in cancer education and training, including biomedical ethics, the responsible conduct of science, biostatistics, bioinformatics, and data sharing. We have a program specific plan for recruiting and retaining a geographically broad range of predoctoral and postdoctoral applicants as well as underrepresented diversity trainees. We have expanded and implemented our cancer didactic and journal oriented courses, both basic and translational. Our domestic eligible predoctoral and postdoctoral applicant pool has almost doubled during the last 4 years and our Faculty Trainer pool has increased by approximately 50%. PUBLIC HEALTH RELEVANCE: This T32 renewal application describes a comprehensive recruitment, training and retention program that combines a strong basic science curriculum with a strong translational cancer focus that distinguishes it from other training programs. Our goals are to train top-quality scientists capable of conducting independent cancer research; foster the intellectual, technical and communication skills required to succeed in the academic or industrial arenas of today and in the future; and to provide an understanding of the basic, public health, and clinical problems of human cancer. During our first review period 50% of all appointees to this T32 have been diversity trainees, our Cancer Biology Program has been fully approved by the Texas Higher Educational Board, UT Southwestern has become a NCI Designated Cancer Center, we have increased our cancer related funding almost 5-fold, and we have increased our student and postdoctoral T32 eligible trainees over 3-fold.