A Twin Study of Negative Valence Emotional Constructs

描述(由申请人提供)：内在性障碍，由焦虑和抑郁的症状组成，代表常见的、令人衰弱的情况，其病因尚不清楚。神经科学家已经开发出维度评估工具和心理任务，探索负价系统作为临床症状的替代表型。这些替代表型正在考虑用于NIMH的研究领域标准(RDoC)项目。然而，目前对它们的遗传基础及其与风险因素内化的关系知之甚少。这项研究将扩大和加深我们对这些替代表型和ID症状的早期表现之间的关系的理解。该方法将从大的流行病学样本中对500对青春期前双胞胎进行一套信息性的维度测量和实验任务。还将评估这些受试者当前和终身内化的精神病理学和一系列广泛的童年风险/保护因素。预期的结果是为基因和环境通过这些更基本的表型赋予内在化障碍风险的机制提供新的见解，这些表型被认为反映了潜在的情感加工。

DESCRIPTION (provided by applicant): Internalizing disorders, consisting of syndromes of anxiety and depression, represent common, debilitating conditions, the etiology of which is not well understood. Neuroscientists have developed dimensional assessment instruments and psychological tasks that probe negative valence systems as alternative phenotypes to clinical symptoms. Such alternative phenotypes are under consideration for use in the NIMH's Research Domain Criteria (RDoC) project. However, little is currently known regarding their genetic basis and how that relates to internalizing risk factors. This study will extend and deepen our understanding of the relationships between such alternative phenotypes and early manifestations of ID symptomatology. The approach will be to administer an informative suite of dimensional measures and experimental tasks to 500 pre-adolescent twin pairs from a large epidemiological sample. These subjects will also be assessed for current and lifetime internalizing psychopathology and a broad array of childhood risk/ protective factors. The expected outcome is to provide novel insights into the mechanisms by which genes and environment confer risk to internalizing disorders via these more basic phenotypes that putatively reflect underlying affective processing.