17th Int. Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism

描述（由申请人提供）：此R13会议补助金正在提交，以支持第17届国际研讨会的酶学和羰基代谢的分子生物学将在宾夕法尼亚州之间举行，7月8日至7月12日，2014年。该研讨会每两年举行一次，轮流在国外和美国举行。该研讨会上一次在美国举行是在2010年，因此，自美国与会者能够轻松参加会议以来，已经过去了四年。会议的重点是参与含羰基底物代谢和解毒的四个主要酶超家族：醇脱氢酶（ADH）;醛脱氢酶（ALDH），短链脱氢酶/还原酶（SDR）;和醛酮还原酶（AKR）。前两个家族与乙醇摄入引起的代谢和毒性密切相关;所有四个家族都在消除有毒醛和酮中发挥作用。每个家庭介绍了结构功能和酶学机制的深入讨论。每个超家族的成员的作用，然后讨论在健康和疾病方面。这包括以下方面的角色：酗酒和酗酒;脂质过氧化副产物的代谢;核受体配体的代谢（例如类维生素A、类固醇激素）;以及在糖尿病、致癌和肿瘤发生中的作用。将强调现代方法的应用，包括生物信息学，功能基因组学，基因敲除和敲入，表达谱和蛋白质组学和代谢组学。会议吸引了在各自领域具有专长的资深科学家，但鼓励新的研究人员与博士前和博士后研究员沿着参加。每个与会者都有机会以口头或海报形式进行介绍。此应用程序仅用于支持学员的旅行。这是会议的文化，没有被邀请的发言者谁支付出席。资深的科学家们自己掏钱。这就降低了会议费用，而且有了赞助，组织者就可以将所有资金用于抵消学员的旅费。没有任何其他会议能把这些领域的研究人员聚集在一起。该研讨会有着丰富的历史，做出了独特的贡献：基因/蛋白质家族命名法起源于研讨会，超过一半的参与者由于参加了一个或多个会议而合作或共同发表。我们预计将有100-120名与会者参加为期4.5天的会议，其中近一半是学员。我们寻求支持至少20名受训人员参加会议。

DESCRIPTION (provided by applicant): This R13 Conference Grant is being submitted to support the 17th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism to be held in Pennsylvania between, July 8- July 12, 2014. The workshop takes place biannually alternating between a foreign and US venue. The workshop was last held in US in 2010 and thus four years have passed since US attendees have had easy access to the meeting. The focus of the meeting is on the four major enzyme superfamilies involved in the metabolism and detoxication of carbonyl containing substrates: the alcohol dehydrogenases (ADH); the aldehyde dehydrogenases (ALDH), the short-chain dehydrogenase/reductases (SDRs); and the aldo-keto reductases (AKRs). The first two families are intimately involved in the metabolism and toxicity resulting from ethanol ingestion; and all four families play roles in the elimination of toxic aldehydes and ketones. Each family is introduced followed by an in-depth discussion of structure-function and mechanistic enzymology. The roles of individual members of each superfamily are then discussed in terms of health and disease. This includes roles in: alcohol abuse and alcoholism; metabolism of by-products of lipid peroxidation; metabolism of ligands for nuclear receptors (e.g. retinoids, steroid hormones); and roles in diabetes, carcinogenesis and oncogenesis. The application of modern approaches including bioinformatics, functional genomics, gene knock-out and knock-in, expression profiling and proteomics and metabolomics will be emphasized. The Conference attracts senior scientists who are expert in their respective fields but new investigators are encouraged to attend along with pre- and post-doctoral fellows. Every attendee has the opportunity to present either orally or in poster format. This application is solely to support the travel of trainees. It is the cultur of the meeting that there are no invited speakers who are paid to attend. Rather senior scientists pay their own way. This keeps meeting costs down and with sponsorship allows the organizers to invest all funds to offset the travel of the trainees. No other conference exists which brings investigators in these fields together. The workshop has a rich history of making unique contributions: gene/protein family nomenclature takes its origins from the workshop and over half the participants have either collaborated or published together as a result of participating i one or more conferences. We anticipate 100-120 attendees to attend the 4.5 day conference with nearly one half being trainees. We seek support for at least 20 trainees to attend the conference.