Pediatric Oncology Clinical Research Training Program

描述(由申请人提供)：本提案构成了由贝勒医学院德克萨斯州儿童癌症中心开发的儿科肿瘤学临床研究培训计划(POCRTP)的续签申请。这一培训计划的前提是，培养在临床研究方面训练有素的儿科肿瘤学家和儿科肿瘤学护士对于在儿童癌症治疗方面继续取得进展至关重要。这份续期申请突显了过去十年来招募的个别学者取得的令人印象深刻的学术成就和进步。该计划旨在提供正式的、全面的、多学科的临床研究教育计划，培训(1)完成为期三年的儿科血液学-肿瘤学奖学金培训计划并在该专科领域获得董事会资格或认证的儿科医生，(2)对儿科肿瘤临床研究有职业兴趣的博士护士。在这一“单轨”计划中，受训人员被指定为“保罗·卡拉布雷西学者”。他们在临床研究试验的设计、实施、实施和分析方面接受两到三年的全面指导培训经验。该计划强调在团队研究环境中进行的治疗研究培训，在团队研究环境中，基础和临床科学家进行互动，以加速将基础研究发现转化为以患者为导向的研究 癌症治疗研究。该计划包括参加贝勒医学院临床科学家培训计划提供的临床研究和试验设计核心教学课程，以及由学员选择的五个专门研究领域之一的深入临床研究培训体验。POCRTP途径包括临床药理学、神经肿瘤学、细胞和基因治疗、血液系统恶性肿瘤或实体瘤。每条路径内的研究经验都是根据个别学者的长期研究目标量身定做的。所有学者都接受实验室研究和临床研究导师的全面指导，并接受关于临床试验设计、统计分析、研究伦理和监管要求和指南的深入指导。此外，学者们还在各自的路径上设计和进行临床试验。国家癌症研究所癌症治疗评估项目的选任轮换是该项目的一个特点。到目前为止的经验表明，完成该项目的学者在临床研究方面训练有素，非常成功地获得了NIH的资助，并处于有利地位，有望成为未来儿科肿瘤学临床研究的领导者。

DESCRIPTION (provided by applicant): This proposal constitutes the renewal application of the Pediatric Oncology Clinical Research Training Program (POCRTP), developed by Baylor College of Medicine's Texas Children's Cancer Center. This training program is predicated on the premise that the development of pediatric oncologists and pediatric oncology nurses who are highly trained in clinical research is essential for continued progress to be made in the treatment of childhood cancer. This renewal application highlights the impressive academic accomplishments and progress of the individual Scholars recruited during the last ten years. The program is structured to provide a formal, comprehensive, multidisciplinary clinical research educational program that trains (1) pediatricians who have completed a three-year pediatric hematology-oncology fellowship training program and are board eligible or certified in that subspecialty and, (2) Ph.D. nurses with a career interest in pediatric oncology clinical research. Trainees, in this "one-track" program, are designated "Paul Calabresi Scholars". They receive a two to three year comprehensive, didactic mentored training experience in the design, implementation, conduct and analysis of clinical research trials. The program emphasizes training in therapeutic research that occurs in team research settings in which basic and clinical scientists interact to expedite the translation of basic research discoveries into patient-oriented therapeutic cancer research. The program includes participation in a core didactic course in clinical investigation and trial design, provided through Baylor College of Medicine's Clinical Scientist Training Program, and an in-depth clinical research training experience focused in one of five specialized research areas, designated "Pathways", chosen by the trainee. The POCRTP Pathways include Clinical Pharmacology, Neuro-oncology, Cell and Gene Therapy, Hematologic Malignancy or Solid Tumors. The research experience within each Pathway is tailored to meet the individual Scholar's long-term research goals. All Scholars receive comprehensive mentorship by both a laboratory research and a clinical research mentor and receive in depth instruction in clinical trial design, statistical analysis, research ethics and regulatory requirements and guidelines. In addition, Scholars design and conduct clinical trials in their respective Pathways. An elective rotation at the National Cancer Institute's Cancer Therapy Evaluation Program is a feature of this program. The experience to date indicates that Scholars who complete this program are exceptionally well trained in clinical research, very successful in obtaining NIH funding and well positioned to become future leaders in pediatric oncology clinical research.