University of Pittsburgh Clinical and Translational Science Institute

2006年，我们创建了匹兹堡大学临床和转化科学研究所（CTSI）， 宾夕法尼亚州西部临床和转化科学的学术之家。我们彻底改变了 在皮特和我们的合作机构，匹兹堡大学医学中心的转化研究 （UPMC），通过培训850名翻译科学家，将团队科学纳入晋升和任期 过程，支持2225名研究人员和4049项研究，并建立一个合作研究 环境我们创建并领导了SPIRiT联盟（6个CTSA中心）和NCATS应计临床 审判网络（21个CTSA中心）。发表了广泛的翻译研究论文的手稿 直接受益于CTSI支持的项目在文献中被引用超过81，000次。在未来5 未来几年，我们将应用我们的基础设施、培训计划、最佳实践和新方法来支持 转化科学和科学家，并通过我们的总体目标推进每个国家CTSA目标： 1)劳动力发展：加强和扩大我们的多元化和团队导向的翻译科学 通过为他们提供晋升所需的专业技能，知识和核心能力， 通过创新的教育方法，体验式培训和持续的 学习机会; 2）协作和参与：参与一个包容性的利益相关者群体， 在整个翻译研究过程中的合作伙伴，并使他们的贡献作为团队成员 进行合作研究; 3）整合：将那些 传统上被排除在外或孤立地研究，并支持和加强跨越生命周期的研究 和转化研究谱; 4）方法/过程：促进创新，质量和效率， 通过开发和传播新的研究方法， 来自CTSA中心、行业和转化科学以外部门的最佳实践;促进项目 管理;以及简化机构研究流程，重点是多中心临床 信息学：在整个研究生命周期中注入信息学工具和方法， 转化研究谱，有效地将研究和临床数据整合到安全的研究数据中 存储库，并实现本地和全国的安全数据共享。除了所需的7个组件和 我们严格的KL 2和TL 1培训计划，我们将扩大我们的成就的范围和广度 通过两个可选组件，利用创新的巨大优势和机会， 学科和生物医学建模。因此，CTSI的影响，其特殊的机构支持， 承诺和热情的团队，将继续是重要的，在当地，区域和国家。

In 2006, we created the University of Pittsburgh Clinical and Translational Science Institute (CTSI) as the academic home for clinical and translational science in western Pennsylvania. We revolutionized the practice of translational research at Pitt and at our partnering institution, the University of Pittsburgh Medical Center (UPMC), by training 850 translational scientists, incorporating team science in the promotions and tenure process, supporting 2225 investigators and 4049 research studies, and forging a collaborative research environment. We created and led the SPIRiT Consortium (6 CTSA hubs) and the NCATS Accrual to Clinical Trials network (21 CTSA hubs). Published manuscripts from a broad range of translational research studies that directly benefitted from CTSI support have been cited >81,000 times in the literature. Over the next 5 years, we will apply our infrastructure, training programs, best practices, and novel approaches to support translational science and scientists and to advance each of the national CTSA goals through our Overall Aims: 1) Workforce Development: Enhance and expand our diverse and team-oriented translational science workforce by providing them with the specialized skills, knowledge, and core competencies required to advance translation of their discoveries through innovative education methods, experiential training, and continuous learning opportunities; 2) Collaboration and Engagement: Engage an inclusive group of stakeholders as partners in the full translational research process and enable their contributions as members of teams conducting collaborative research; 3) Integration: Integrate into research programs those populations that have been traditionally excluded or studied in isolation and support and enhance studies that span the lifespan and translational research spectrum; 4) Methods/Processes: Promote innovation, quality, and efficiency across the translational research spectrum by developing and disseminating new research methodologies; adopting best practices from CTSA hubs, industry, and sectors outside of translational science; facilitating project management; and streamlining institutional research processes, with an emphasis on multi-center clinical trials; and 5) Informatics: Infuse informatics tools and methodologies across the research life cycle and translational research spectrum, efficiently integrate research and clinical data in a secure research data repository, and enable secure data sharing locally and nationally. In addition to the 7 required Components and our rigorous KL2 and TL1 training programs, we will expand our range and breadth of accomplishments through two Optional Components that leverage great strengths and opportunities in Innovation as a Discipline and Biomedical Modeling. Thus, the impact of CTSI, with its exceptional institutional support and committed and enthusiastic team, will continue to be significant, locally, regionally, and nationally.