Neuroimaging Core

项目摘要/摘要：神经成像核心 NIA-Layton老龄化和阿尔茨海默氏症中心(NIA/LAADC)在本文中被称为俄勒冈州ADC或 OADC，有20多年的实质性纵向神经成像研究历史，重点是健康 老年人早期痴呆的年龄、轻度认知损害(MCI)和MRI标记物，包括 来自1000多个受试者的3700多个磁共振成像的广泛的纵向数据库。随着美国政府的成立 OHSU高级成像研究中心(AIRC)，OADC神经成像实验室最近实施了 先进的成像序列和分析技术，以加深我们对相关MRI标记的理解 与年龄相关的认知和运动功能的变化，包括健康的衰老，早期的认知衰退，以及 血管疾病和白质完整性的影像标记物。这些进步使得OADC 神经成像实验室合作并促进OHSU内外的大脑老化的MRI研究。这个 OADC神经成像实验室支持AD和相关疾病的活体3T MRI采集和分析，具有 对血管性认知障碍和痴呆(VCID)的额外关注。除了先进的活体核磁共振 协议，我们开发了一种7T人脑组织死后成像协议，用于靶向 MRI定义的组织病理学感兴趣区取样。OHSU放射性核素的最新加入 研究中心(RRC)推动了旨在提供新型神经成像的持续开发工作 向OHSU社区推广AD相关研究的技术，包括tau-PET成像。这 应用程序建议继续巩固并在这些进展的基础上建立一个 OADC神经成像核心，包括体内和死后检测早期大脑的MRI方法 与痴呆症高危老年人认知能力下降相关的变化。建议的具体目标 神经成像的核心是：1)获得并提供研究、最先进的神经成像 来自OADC受试者的获取和高级MRI处理，包括：健康对照、MCI和 那些患有阿尔茨海默病和其他痴呆的人，2)获得并提供研究、神经成像数据 关于OADC主题，以及3)促进涉及神经成像的合作研究，并加强 其他核心资源的利用。核心支持的影像研究主题将包括：1)健康 年龄与认知损害的早期影像指标，2)脑血管疾病对认知功能的影响 功能和痴呆症风险，以及3)旨在维持老年人认知的治疗和预防试验。 最终，这个神经成像核心将为OADC提供迫切需要的资源来追求和发展 新的MRI序列和分析技术，可用于当前和未来的衰老研究。总而言之，这种神经成像 CORE将极大地促进我们在OHSU内外合作的能力，以推进我们的 对年龄相关认知变化的理解。

Project Summary/Abstract: Neuroimaging Core The NIA - Layton Aging & Alzheimer’s Disease Center (NIA/LAADC) herein referred to as the Oregon ADC or OADC, has a 20+ year history of substantive longitudinal neuroimaging research, with a focus on healthy aging, mild cognitive impairment (MCI) and MRI markers of early dementia in the elderly, and includes an extensive longitudinal database of over 3700 MRI’s from over 1000 subjects. With the establishment of the OHSU Advanced Imaging Research Center (AIRC), the OADC neuroimaging lab has recently implemented advanced imaging sequences and analysis techniques to further our understanding of MRI markers associated with age-related changes in cognitive and motor function, including healthy aging, early cognitive decline, and imaging markers of vascular disease and white matter integrity. These advances, have allowed the OADC neuroimaging lab to collaborate and foster MRI research in brain aging both within and outside of OHSU. The OADC neuroimaging lab supports in vivo 3T MRI acquisition and analysis of AD and related disorders, with an additional focus on vascular cognitive impairment and dementia (VCID). In addition to advanced in vivo MRI protocols, we have developed a 7T post-mortem imaging protocol of human brain tissue for the targeted sampling of MRI-defined regions of interest for histopathology. The recent addition of the OHSU Radionuclear Research Center (RRC) has enabled continued development efforts aimed at providing of novel neuroimaging technologies promoting AD-related research to the OHSU community, including tau-PET imaging. This application proposes to continue to consolidate and substantially build upon these advances by establishing an OADC neuroimaging core, that would include both in vivo and post-mortem MRI methods to detect early brain changes associated with cognitive decline in elderly at risk for dementia. The Specific Aims of the proposed Neuroimaging Core are: 1) To obtain and make available for research, state of the art, neuroimaging acquisition and advanced MRI processing from OADC subjects, including: healthy controls, MCI, and those with AD and other dementias, 2) To obtain and make available for research, neuroimaging data on OADC subjects, and 3) To foster collaborative research involving neuroimaging, and enhance utilization of other core resources. Imaging research themes supported by the core will include: 1) healthy aging and early imaging markers of cognitive impairment, 2) the role of cerebrovascular disease on cognitive function and dementia risk, and 3) treatment and prevention trials aimed at maintaining cognition in the elderly. Ultimately, this neuroimaging core will provide the OADC with a much needed resource to pursue and develop novel MRI sequence and analysis techniques for current and future aging studies. In total, this neuroimaging core would greatly facilitate our ability to collaborate both within and outside OHSU to advance our understanding of age-related cognitive changes.