Scripps Translational Science Institute
Scripps Translational Science Institute
批准号:
9265535
负责人:
Eric Jeffrey Topol
金额:
$492.85万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-26 至 2018-04-30
关键词:
Adverse effectsAnatomyAreaBioinformaticsBiologicalBiosensorClinical ResearchClinical SciencesCommunitiesCountryDataData SecurityDiagnosisDiseaseEnvironmentFosteringFoundationsFutureGenomicsGrantHealthHealthcareHealthcare SystemsHumanIndividualInstitutesInstitutionMass ScreeningMedicalMedicineMethodsPatientsPharmaceutical PreparationsPhysiologicalPublic HealthResearchResearch InfrastructureResearch InstituteResourcesScienceScientistServicesTalentsTraining SupportTraining and EducationTranslational ResearchUnited StatesUnited States National Institutes of HealthWireless Technologycareer developmentclinical practicecostcost effectivedigitaldrug discoveryeffective therapyhuman datahuman genomicshuman subject protectionimprovedindividualized medicineinformatics infrastructureinnovationprogramssupercomputertoolwhole genome
中文摘要
斯克里普斯翻译科学研究所(STSI)旨在支持和催化有影响力的翻译和
不仅是斯克里普斯研究所的临床研究,包括斯克里普斯研究所和
斯克里普斯健康,也是一个广泛的合作调查网络,从La Jolla Mesa延伸
整个美国。斯克里普斯计划结合了美国最大的独立生物医学研究所
在圣地亚哥拥有占主导地位的医疗保健系统的国家,以及与
圣地亚哥超级计算机中心,同类4个国家资源中心之一。我们的创新领域
基础设施包括信息学、基因组学和无线医学。每个领域都有显著的变革性
为医学的未来和改善公众的健康提供了潜力。基因组学和基因组学的主要进展
无线技术创造了以前无法想象的数据洪流,但具有先进的
分析能力使用这些数据来个体化医学,定义
每个独特的人类都处于多个层面--生物学、生理学和解剖学。
通过个体化用药,为更有效的治疗提供了科学依据,避免了严重的
副作用,一种更精确的提供医疗保健的手段,并降低成本。每个人的数据
信息可以通过无线生物传感器或对整个基因组进行排序等新工具来捕获
基因组。STSI在这些工具方面拥有特殊的专业知识,这不仅包括收集数据,还包括
卓越的分析能力。这建立了一个创新的基础设施,以提供疾病不可知
为高效的研究网络提供资源和服务-该网络已经打破了
以前存在的基础科学家和临床医生。此外,这些资源还支持培训和
面向未来的医学带头人的职业发展。
英文摘要
The Scripps Translational Science Institute (STSI) aims to support and catalyze impactful translational and
clinical research for not only the Scripps institutions, consisting of The Scripps Research Institute and
Scripps Health, but also an extensive collaborating investigative network that extends from the La Jolla Mesa
throughout the United States.The Scripps program combines the largest independent biomedical institute in
the country with the dominant health care system in San Diego, along with an extensive partnership with the
San Diego Supercomputer Center, one of the 4 national resource centers of its kind. Our areas of innovative
infrastructure are informatics, genomics, and wireless medicine. Each area has a remarkably transformative
potential for the future of medicine and improving the health of the public. Major advances in genomics and
wireless technologies have created data torrents that were previously unimaginable, but with advanced
analytical capabilities there is a remarkable opportunity to use such data to individualize medicine, defining
each unique human being at multiple levels - biological, physiological, and anatomical.
By individualizing medicine, there is a scientific foundation for more effective treatments, avoidance of major
side effects, a far more precise means of rendering health care, and lowering of costs. Each individual's data
and information can be captured with such new tools as wireless biosensors or sequencing of the entire
genome. STSI has particular expertise in these tools, which includes not only gathering the data but also
superior analytical capabilities. This sets up an innovative infrastructure to provide disease-agnostic
resources and services for a highly productive research network - one that has dismantled the silos that
previously existed of basic scientists and clinicians. Furthermore, these resources support the training and
career development of the leaders of medicine for the future.
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Off the cuff: rebooting blood pressure treatment.
即兴:重新启动血压治疗。
DOI:
10.1016/s0140-6736(16)31348-4
发表时间:
2016
期刊:
Lancet (London, England)
影响因子:
--
作者:
[Steinhubl,StevenR, Muse,EvanD, Barrett,PaddyM, Topol,EricJ]
通讯作者:
Topol,EricJ
DOI:
10.7717/peerj.1554
发表时间:
2016
期刊:
PeerJ
影响因子:
2.7
作者:
[Bloss CS, Wineinger NE, Peters M, Boeldt DL, Ariniello L, Kim JY, Sheard J, Komatireddy R, Barrett P, Topol EJ]
通讯作者:
Topol EJ
Privacy and security in the era of digital health: what should translational researchers know and do about it?
数字健康时代的隐私和安全:转化研究人员应该了解什么并采取什么措施?
DOI:
--
发表时间:
2016
期刊:
American journal of translational research
影响因子:
2.2
作者:
[Filkins,BarbaraL, Kim,JuYoung, Roberts,Bruce, Armstrong,Winston, Miller,MarkA, Hultner,MichaelL, Castillo,AnthonyP, Ducom,Jean-Christophe, Topol,EricJ, Steinhubl,StevenR]
通讯作者:
Steinhubl,StevenR
DOI:
10.1089/dia.2015.0283
发表时间:
2016-04
期刊:
Diabetes technology & therapeutics
影响因子:
5.4
作者:
[Anzaldo-Campos MC, Contreras S, Vargas-Ojeda A, Menchaca-Díaz R, Fortmann A, Philis-Tsimikas A]
通讯作者:
Philis-Tsimikas A
DOI:
10.2196/jmir.6371
发表时间:
2016-11-17
期刊:
Journal of medical Internet research
影响因子:
7.4
作者:
[Kim JY, Wineinger NE, Taitel M, Radin JM, Akinbosoye O, Jiang J, Nikzad N, Orr G, Topol E, Steinhubl S]
通讯作者:
Steinhubl S
共 23 条
Scripps Clinical and Translational Science Hub
-
批准号:10621679
-
项目类别:
-
资助金额:$602.98万
-
财政年份:2023
-
负责人:Eric Jeffrey Topol
-
依托单位:
The Participant Center: Empowering All of Us Research Program participation across the United States
-
批准号:10774158
-
项目类别:
-
资助金额:$5400.0万
-
财政年份:2023
-
负责人:Eric Jeffrey Topol
-
依托单位:
Technology to Empower Changes in Health (TECH) Network Participant Technologies Center
-
批准号:10013434
-
项目类别:
-
资助金额:$944.61万
-
财政年份:2019
-
负责人:Eric Jeffrey Topol
-
依托单位:
Scripps Translational Science Institute
-
批准号:10173181
-
项目类别:
-
资助金额:$9.78万
-
财政年份:2018
-
负责人:Eric Jeffrey Topol
-
依托单位:
Scripps Translational Science Institute
-
批准号:10159148
-
项目类别:
-
资助金额:$18.27万
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财政年份:2018
-
负责人:Eric Jeffrey Topol
-
依托单位:
Scripps Translational Science Institute
-
批准号:10159338
-
项目类别:
-
资助金额:$575.94万
-
财政年份:2018
-
负责人:Eric Jeffrey Topol
-
依托单位:
Scripps Translational Science Institute
-
批准号:10401476
-
项目类别:
-
资助金额:$575.94万
-
财政年份:2018
-
负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:10660851
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项目类别:
-
资助金额:$13.22万
-
财政年份:2018
-
负责人:Eric Jeffrey Topol
-
依托单位:
Technology to Empower Changes in Health (TECH) Network Participant Technologies Center
-
批准号:10368012
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项目类别:
-
资助金额:$2237.89万
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财政年份:2016
-
负责人:Eric Jeffrey Topol
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依托单位:
Technology to Empower Changes in Health (TECH) Network Participant Technologies Center
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批准号:10011913
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项目类别:
-
资助金额:$3341.99万
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财政年份:2016
-
负责人:Eric Jeffrey Topol
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依托单位:
Technology to Empower Changes in Health (TECH) Network Participant Technologies Center
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批准号:10684957
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项目类别:
-
资助金额:$1560.18万
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财政年份:2016
-
负责人:Eric Jeffrey Topol
-
依托单位:
Scripps Translational Science Institute
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批准号:8916876
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项目类别:
-
资助金额:$11.27万
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财政年份:2013
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负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:8743357
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项目类别:
-
资助金额:$537.87万
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财政年份:2013
-
负责人:Eric Jeffrey Topol
-
依托单位:
Scripps Translational Science Institute
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批准号:9062543
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项目类别:
-
资助金额:$20.32万
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财政年份:2013
-
负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:9062544
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项目类别:
-
资助金额:$530.93万
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财政年份:2013
-
负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:9062542
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项目类别:
-
资助金额:$78.21万
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财政年份:2013
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负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:8743355
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项目类别:
-
资助金额:$71.57万
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财政年份:2013
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负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:9265537
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项目类别:
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资助金额:$31.68万
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财政年份:2013
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负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:8721045
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项目类别:
-
资助金额:$19.45万
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财政年份:2013
-
负责人:Eric Jeffrey Topol
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依托单位:
Scripps Translational Science Institute
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批准号:8871826
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项目类别:
-
资助金额:$20.02万
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财政年份:2013
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负责人:Eric Jeffrey Topol
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依托单位:
海外基金