Chronic Effects of Neurotrauma Consortium (CENC) Epidemiology Study

该项目的主要目标是通过集成和 以新颖的方式分析它们，以回答与轻度脑外伤的慢性影响有关的关键问题。 随着时间的推移，退伍军人的伤害（mTBI）。虽然先前的研究发现，中度和重度TBI是 与各种不良临床结果相关，mTBI的影响还不太清楚。我们 建议通过四个互补的具体目标来弥补这一知识差距。在目标1中，我们建议 检查mTBI与重要的短期临床结果（如事故）之间的关联， 最近在伊拉克和阿富汗冲突中受伤的退伍军人，重点是确定相关因素， 具有复原力和适当治疗的潜在益处。在目标2中，我们建议扩展这些 分析包括所有时代的退伍军人，并研究长期临床结局，包括神经感觉 疾病和死亡率，重点关注共病医学状况的潜在混杂效应和 他们的待遇的影响。在目标3中，我们提出识别mTBI相关共病的不同轨迹， 负担，目标是确定与处于低和高痛苦轨迹相关的因素。最后在 目标4，我们建议通过以下方式为未来使用更详细和统一的mTBI数据进行分析奠定基础： 为建立国家CENC数据储存库（NCDR）奠定基础。总之，这些目标将 推进我们对所有年龄和时代的退伍军人中mTBI对重要临床结果的影响的认识 这将有助于深入了解潜在的预防和干预战略。

The primary objective of this project is to capitalize on a variety of existing data sources by integrating and analyzing them in novel ways to answer key questions related to the chronic effects of mild traumatic brain injury (mTBI) in Veterans over time. Although prior studies have found that moderate and severe TBI are associated with a variety of adverse clinical outcomes, the effects of mTBI are less well understood. We propose to address this gap in knowledge through four complimentary Specific Aims. In Aim 1, we propose to examine the association between mTBI and important shorter-term clinical outcomes such as accidents and injuries in Veterans from recent conflicts in Iraq and Afghanistan, focusing on identifying factors associated with resilience and the potential benefits of adequate treatment. In Aim 2, we propose to expand these analyses to include Veterans from all eras and to study longer-term clinical outcomes including neurosensory disorders and mortality, focusing on the potential confounding effects of comorbid medical conditions and the impact of their treatment. In Aim 3, we propose to identify different trajectories of mTBI-related comorbid burden, with the goal of identifying factors associated with being in low and high distress trajectories. Finally, in Aim 4, we propose to lay the groundwork for future analyses using more detailed and unified mTBI data by developing the groundwork to create a National CENC Data Repository (NCDR). Together, these Aims will advance our knowledge of the effects of mTBI on important clinical outcomes in Veterans of all ages and eras in a highly efficient manner and will provide insight into potential strategies for prevention and intervention.