New Directions in Palladium/Norbornene Cooperative-Renewal

翻译后摘要：我们正在从事系统的努力，以开发新的，有效的，广泛有用的 Pd/NBE催化芳烃/杂芳烃邻位双 功能化和一步羰基1，2-转座。我们在拟议拨款中的目标 阶段包括首先实现先前前所未有芳基卤化物的邻位氧化 通过一类新的亲电体使能;第二，开发五种亲电体的直接邻位双官能化， 第三，通过氧化和氧化还原中性的方法， 一步羰基1，2-转座反应。这项研究预计将发现新的 合成方法和有效的催化剂体系，这应该提供一般的和不同的 获得多取代芳烃和杂环的方法通常存在于 或有效地重新定位复杂分子中的羰基以产生 新的“官能团转移”类似物。

Abstract: We are engaged in the systematic efforts to exploit new, efficient, and broadly useful palladium/norbornene (Pd/NBE) catalysis for site-specific arene/heteroarene vicinal di- functionalization and one-step carbonyl 1,2-transposition. Our objectives in the proposed funding period include first to realize a previously unprecedented ortho oxygenation of aryl halides enabled by a new class of electrophile; second to develop direct vicinal difunctionalization of five- membered heteroarenes via both oxidative and redox-neutral approaches; and third to enable a one-step carbonyl 1,2-transposition reaction. The proposed research is expected to identify new synthetic methods and efficient catalyst systems, which should provide general and distinct approaches to access poly-substituted arenes and heterocycles commonly found in pharmaceuticals or to efficiently relocate carbonyl groups in complex molecules for generating novel “functional group-shifted” analogues.