Rush Alzheimer's Disease Research Center

摘要--总体 拟议的Rush ADRC的总体目标是创造一个跨学科的环境，以支持 对AD/ADRD的原因、治疗和预防进行创新研究。虽然拟议的Rush ADRC 是一项新的拨款，它建立在现任Rush ADCC 30年来的工作基础上。Rush ADRC有八个 核心和一个组成部分，与2017年国家投资局战略计划的建议保持一致，包括 研究表明：1)认识到痴呆症的异质性和多因素性质；2)广泛支持 分子图谱，以填补建立疾病预测模型所需的大规模人类数据的空白 健康；3)采用新的研究范式，例如系统生物学、人体细胞建模；4)使快速和 广泛共享数据、疾病模型、样本，并支持开放和团队科学；5)开发 用于存储、集成和分析大规模生物和生物的计算工具和基础设施 与患者相关的数据；6)在虚拟和真实空间中建立多学科翻译团队；7)开发新的 竞争前的公私伙伴关系；8)改变学术、出版和资金激励措施，以促进 协作、透明和可重复的研究；以及9)让患者、护理人员和公民 研究方面的直接合作伙伴。 行政核心将为Rush ADRC作为一个整体提供科学领导。宗教教团 研究(ROS)核心将招募和进行年度评估的非痴呆症天主教神职人员谁同意 器官捐献。临床和拉丁裔核心将收集与黑人和拉丁裔协调的数据，而不包括 痴呆症和脑部尸检。神经病理核心将处理、存储、评估和 分发由临床、ROS和拉丁裔核心获得的生物样品。外展、招聘和 Engagement Core将提供广泛的教育计划，以支持外展和招聘 将少数族裔和少数族裔纳入临床、ROS和拉丁裔核心，以及由NIA资助的其他倡议。这个 BioMarker/神经成像核心将处理与其他基金从所有三个核心和 附属研究，并记录神经成像和生物流体生物标记物数据。新研究与新教育 该部分将为所有级别的学生和教职员工提供有组织的指导。数据管理和 统计核心将提供基础架构，允许所有其他核心和REC最大限度地 成功和有影响力，并将为ADRC资源的用户，特别是初级用户提供统计支持 调查员和实习生。

ABSTRACT – OVERALL The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on the causes, treatments, and prevention of AD/ADRD. While the proposed Rush ADRC is for a new grant, it builds on three decades of work by the current Rush ADCC. The Rush ADRC has eight cores and one component, which align with the recommendations of the 2017 NIA strategic plan, including studies that: 1) recognize the heterogeneity and multifactorial nature of dementias; 2) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; 3) employ new research paradigms, e.g., systems biology, human cell modeling; 4) enable rapid and extensive sharing of data, disease models, specimens, and support open and team science; 5) develop computational tools and infrastructure for storage, integration, and analysis of large-scale biological and patient-relevant data; 6) build multidisciplinary translational teams in virtual and real spaces; 7) develop new pre-competitive public-private partnerships; 8) change academic, publishing, and funding incentives to promote collaborative, transparent, and reproducible research; and 9) engage patients, caregivers, and citizens as direct partners in research. The Administrative Core will provide scientific leadership to the Rush ADRC as a whole. The Religious Orders Study (ROS) Core will recruit and conduct annual evaluations of Catholic clergy without dementia who agree to organ donation. The Clinical and Latino Cores will collect data harmonized with on Blacks and Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach, Recruitment, and Engagement Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical, ROS and Latino Cores, and other NIA funded initiatives. The Biomarker/Neuroimaging Core will process neuroimaging generated with other funds from all three Cores and affiliated studies, and document neuroimaging and biofluid biomarker data. The new Research and Education Component will provide structured mentoring of students and faculty at all levels. The Data Management and Statistical Core will provide the infrastructure that allows all other Cores and the REC to be maximally successful and impactful and will provide statistical support to users of ADRC resources especially junior investigators and trainees.