Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations-Administrative Supplement for Increased Costs

增加的费用补充--ADRD风险的种族/民族差异：影响 社会关系学 现申请国家安全局行政副刊，以解决 在COVID之后的两年延迟带来了前所未有的成本增长- 19强制面对面数据收集关闭。我们注意到，没有 改变原定资助的项目范围：消除种族歧视中的种族/族裔差距 风险：社会关系的影响(R01AG057510)。尽管耽搁了，但没有任何干预 研究降低了拟议研究的重要性或独特性，这 提供了一个史无前例的机会来推进对 哪些社会关系的横向和纵向模式与 ADRD风险。具体目标是：1)审查社会关系的世俗趋势和 按种族/族裔分列的两个成人寿命区域代表性队列中的健康状况；2)确定 对黑人中的ADRD风险影响最大的社会关系方面， 中老年白人和阿拉伯裔美国人；3)确定纵向联系 生活中的社会关系和黑人和白人之间的ADRD风险之间的关系。 提交本附录的目的是为了保持原批准的 研究的目的、目的和预期的总体影响。两年的COVID 延迟对这项开创性研究的打击尤其严重，并在财务上造成了毁灭性的影响。我们 利用现有的对30岁以上详细社会关系的纵向队列研究 在不同的寿命样本中的年龄(即在第一波中从8岁到93岁)。添加认知性 和遗传措施，以及扩大种族/民族群体比较，以包括 阿拉伯裔美国人在一个新的具有地区代表性的样本(35岁以上)中提供了一部小说 研究中年ADRD风险的可修改因素的机会。调查结果将提供关键 利用有影响力的社会关系资源制定战略的信息 缩小差距。此外，拟议的研究为一位新的代表奠定了基础 ADRD风险的种族/民族差异的纵向研究。

Increased Costs Supplement- Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations This application for a NIA Administrative Supplement is requested to address the unprecedented cost increases arising from the two-year delay that followed the COVID- 19 mandatory face-to-face data collection shutdown. We note that there has been no change in the original funded scope of the project Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations (R01AG057510). Despite the delay, no intervening research has reduced the importance or uniqueness of the proposed study, which provides an unprecedented opportunity to advance the scientific study of the ways in which cross-sectional and longitudinal patterns of social relations link with disparities in ADRD risk. The specific aims are to: 1) Examine secular trends in social relations and health by race/ethnicity in two adult lifespan regionally representative cohorts; 2) Identify aspects of social relations that have the greatest effects on ADRD risk among blacks, whites and Arab Americans in mid- and late- life; 3) Identify longitudinal associations between social relations across the life course and ADRD risk among blacks and whites. This supplement is submitted to preserve the integrity of the originally approved objectives, purpose and expected overall impact of the study. The two-year COVID delay hit this pioneering study especially hard and has been financially devastating. We capitalize on an existing longitudinal cohort study of detailed social relations over ~30 years in a diverse lifespan sample (i.e., from age 8 to 93 in Wave 1). Adding cognitive and genetic measures, as well as extending racial/ethnic group comparisons to include Arab Americans in a new regionally representative sample (age 35+) provides a novel opportunity to study modifiable factors in midlife for ADRD risk. Findings will provide key information to develop strategies using the influential resource of social relations to reduce disparities. Further, the proposed study sets the stage for a newly representative longitudinal study of racial/ethnic disparities in ADRD risk.