USC/UCLA Center on Biodemography and Population Health: Enhanced Contextual Data Resource (CDR) for Understanding the AD/ADRD Exposome

项目摘要 这是南加州大学/加州大学洛杉矶分校生物人口学和人口健康中心的补充申请 （CBPH）（P30 AG 017265）创建增强的上下文数据资源（CDR），以了解 AD/ADRD暴露体。CBPH提供了一个协同研究环境，支持各种活动， 增进对有助于人口健康和保健的社会和生物过程的了解 老年人的差异。物理、化学和社会环境暴露构成了 烦恼无疑在塑造生命过程中的健康方面发挥着重要作用，但 AD/ADRD结局的困扰尚未完全了解。研究的主要挑战之一是 AD/ADRD的麻烦是缺乏关于环境暴露的现成和可重复的数据。的 背景数据的获取、管理和分析所固有的困难， 新用户和有经验的用户的障碍。这些障碍包括获取和使用这些服务的前期成本高， 处理数据，以便随着时间的推移将其与调查受访者联系起来，需要投入大量时间， 建立环境背景的概括和纵向衡量标准，以及缺乏如何使用这些标准的培训。 健康和衰老模型中的数据。该补充通过利用中心的 在建立数据资源及其数据传播和用户基础设施方面的现有专门知识 支持创建全面的AD/ADRD曝光重点CDR。通过这一行政 作为补充，我们将大大增强围绕麻烦数据的研究基础设施， 数据集的空间覆盖范围，并创建更多的用户资源， 既有已建立的研究人员，也有AD/ADRD领域和/或地理和 环境研究。拟议的补充活动还将利用新获得的数据 飞地，以提供更快的传播这一数据资源的研究人员社区， 特别是AD/ADRD。

PROJECT SUMMARY This is an application for a supplement to the USC/UCLA Center on Biodemography and Population Health (CBPH) (P30AG017265) to create an Enhanced Contextual Data Resource (CDR) for Understanding the AD/ADRD Exposome. The CBPH provides a synergistic research environment that supports activities to enhance understanding of the social and biological processes that contribute to population health and health disparities at older ages. The physical, chemical, and social environmental exposures that constitute the exposome undoubtedly play an important role in shaping health over the life course, but the impact of the exposome on AD/ADRD outcomes is not fully understood. One of the major challenges in research on the AD/ADRD exposome is the lack of readily available and linkable data on environmental exposures. The difficulties inherent to the acquisition, management, and analysis of contextual data represent a formidable barrier for both new and experienced users. These barriers include the high up-front costs of obtaining and processing data so it can be linked to survey respondents over time, intensive time commitments required to create summary and longitudinal measures of environmental context, and lack of training in how to use such data in models of health and aging. This supplement overcomes these barriers by leveraging the Center’s existing expertise in building data resources as well as its infrastructure for data dissemination and user support to create a comprehensive AD/ADRD exposome focused CDR. Through this administrative supplement we will greatly enhance the research infrastructure around exposome data with improved temporal and spatial coverage of data sets and the creation of additional user resources to facilitate use of the data by both established researchers and those who are new to the AD/ADRD field and/or geographic and environmental research. The proposed supplemental activities will also take advantage of newly available data enclaves to provide even more rapid dissemination of this data resource to the community of researchers in aging, and specifically AD/ADRD.