Human Plasma Cell Maturation & Maintenance through CD138, TNFRSF, and Modulation of Ig Secretion

摘要： 人长寿命浆细胞（LLPC）存在于骨髓（BM）中，并负责骨髓细胞的长期增殖。 维持血清抗体水平。BM显微结构提供了重要的因素， 将早期产生的抗体分泌细胞（ASC）转化为LLPC，其中CD 138和BCMA - TNF受体超家族（TNFRSF）-起重要作用。在这个应用程序中，我们探索旧的和新的 BM微粒中的CD 138结合因子以及长期建立的和新发现的TNFRSF成员， LLPC的发展，以及了解如何调节抗体的高能功能， 分泌决定LLPC存活。如果成功，该应用程序将提供重要的基本机制， 用于持久的疫苗设计。

Abstract: Human long-lived plasma cells (LLPC) reside in the bone marrow (BM) and are responsible for the long-term maintenance of serum antibody levels. The BM microniche provides important factors to fundamentally transform early-minted antibody secreting cells (ASC) into LLPC for which CD138 and BCMA - a member of the TNF receptor superfamily (TNFRSF) - play an important role. In this application, we explore old and new CD138 binding factors in the BM microniche and long-established and newly discovered TNFRSF members in the development of LLPC, as well as understanding how modulating the high energy function of antibody secretion determines LLPC survival. If successful, this application will provide the basic mechanisms important for durable vaccine design.