Multidisciplinary Training in Environmental Toxicology

项目摘要/摘要 密歇根大学多学科环境与综合毒理学(EITS)培训计划 州立大学(MSU)培养出具备环境毒理学基础知识的科学家 生物医学基础科学研究生项目的研究。博士前实习生必须获得完整的博士学位 合作生物医学博士项目的要求，并完成课程工作、研究和 通过综合毒理学研究所管理的EITS博士项目的互动方面 (IIT)。培训的两面性在《生物医学科学-环境毒理学》的标题中得到了承认 授予学位(例如，“生物化学和分子生物学-环境毒理学”博士学位)。毕业于 这些项目都有能力成为各自领域的领导者，并进行有能力进行的研究 解决复杂的环境毒理学问题需要多学科的协作 接近了。25名培训教师在9个基础科学博士项目中进行博士前培训 (生物化学与分子生物学、细胞与分子生物学、比较医学与综合生物学、 食品科学与人类营养学、遗传学、微生物学与分子遗传学、神经科学、药理学 毒理学和生理学)。增加了以生物医学为基础的教育和环境 毒理学研究培训是EITS的教学性、面向毒理学的课程和其他要求 程序。本课程由IIT提供的课程、职业发展机会和多学科活动 传授比仅在基础科学项目中可获得的更广泛的知识。研究课题： 受训者跨越不同的器官系统，包括基因-环境相互作用和 疾病易感性和进展中的环境应激源。综合生物学是这项研究的核心 培训，强调整体动物、基于细胞的、分子和各种“组学”方法论的理解 合作气氛中的不良后果和毒性机制。博士后培训计划 不仅包括在培训教师的实验室进行研究，还包括获得更多 通过跟踪个人发展获得环境毒理学经验和职业发展机会 计划(IdP)。此外，还鼓励参加IIT和大学范围内的活动，以扩大 培训经验。此申请请求7名博士后和2名博士后实习生的支持， 从而继续一个高效的多学科和互动的培训计划，将正式和 为毕业生在研究中担任领导角色做准备的非正式方法，旨在促进我们的 了解暴露于环境化学品的不良后果。

PROJECT SUMMARY/ABSTRACT The multidisciplinary Environmental and Integrative Toxicological Sciences (EITS) Training Program at Michigan State University (MSU) produces scientists with a base knowledge in environmental toxicology coupled with research in a biomedical basic science graduate program. Predoctoral trainees must meet the full PhD requirements of their partnering biomedical doctoral program and complete the coursework, research and interactive aspects of the EITS Doctoral Program administered through the Institute for Integrative Toxicology (IIT). The dual nature of the training is recognized in the biomedical science-environmental toxicology title of the degree awarded (e.g., PhD in “Biochemistry and Molecular Biology-Environmental Toxicology”). Graduates of the program are well equipped to become leaders in their respective fields and conduct research capable of addressing complex environmental toxicological problems that require collaborative, multidisciplinary approaches. Twenty-five training faculty conduct predoctoral training in nine basic science PhD programs (Biochemistry and Molecular Biology, Cell and Molecular Biology, Comparative Medicine and Integrative Biology, Food Science and Human Nutrition, Genetics, Microbiology and Molecular Genetics, Neuroscience, Pharmacology and Toxicology, and Physiology). Added to the basic biomedical science-based education and environmental toxicology research training are didactic, toxicology-oriented courses and other requirements of the EITS Program. This coursework, career development opportunities and multidisciplinary activities provided by the IIT impart a wider scope of knowledge than is available within basic science programs alone. Research topics for trainees span various organ systems and encompass gene-environment interactions and the role of environmental stressors in disease susceptibility and progression. Integrative biology is central to the research training, which emphasizes whole animal, cell-based, molecular and various “omic” methodologies to understand adverse outcomes and mechanisms of toxicity in a collaborative atmosphere. The postdoctoral training program involves not only conducting research in the laboratories of the training faculty but also gaining additional environmental toxicology experience and career-building opportunities by following an individual development plan (IDP). In addition, participation in IIT and University-wide activities is also encouraged to broaden the training experience. This application requests support of seven predoctoral and two postdoctoral trainees, thereby continuing a highly effective multidisciplinary and interactive training program that combines formal and informal approaches to prepare graduates for leadership roles in research that aims to advance our understanding of adverse outcomes from exposure to environmental chemicals.