CSHL 2023 Conference on Microbial Pathogenesis & Host Response

微生物致病机理与寄主反应 2023年9月11日至15日 摘要 第十四届微生物致病机理和宿主反应国际会议将重点关注 研究传染病的跨学科方法，整合分子微生物学的学科， 真核细胞生物学、免疫学和基因组学。微生物疾病再次成为一种重要的 在世界卫生保健中的中心作用，由于新病原体的出现，共同疾病的重新兴起 病原体和广泛的抗药性。在人类健康之外，毁灭性的大流行正在破坏稳定 生态系统，棕色蝙蝠和两栖动物目前受到极端威胁。这次会议将提供一个内部- 深度关注用来阐明细菌和真菌机制的方法 发病机制，并促进将这些概念应用于控制和干预的新策略 传染病的风险。口头会议和海报会议将集中讨论微生物致病的主要新兴主题 以及宿主的反应，包括：微生物疾病的发病机制；宿主的分子调控-- 病原菌相互作用、寄主细胞/病原菌相互作用生物学和病原菌逃避策略的多样性 先天免疫力。这些会议将整合关于细菌和真菌病原体的研究。口头会议将 首先由该领域的知名领导者邀请2-3次演讲，然后从以下几个较短的演讲中选择 提交的摘要。个别会议的广泛主题包括：(1)微生物毒素和效应物在 微生物疾病；(2)感染期间的基本细胞生物学相互作用；(3)对 微生物感染(4)宿主-微生物相互作用的关键分子调控；(5)健康中的微生物群落 和疾病，以及(6)使用最先进的技术来可视化宿主与病原体的相互作用。包括 两次海报会议以及在每次演讲后分配充足的提问时间将鼓励 与会者进行了广泛的讨论。会议规模将足够小(250-350名科学家)，以便于 这些互动，但足够大，不仅允许来自老牌调查人员的口头陈述，而且 也来自初级调查人员和那些具有新奇视角的人。整合了各种不同的方面 细菌和真菌的致病机理与宿主对病原体的反应应促进新的交叉学科 在关于微生物发病机制的其他会议上很少实现的相互作用，或者更狭隘地 聚焦或如此多样化，以至于主题很难整合。由此产生的跨学科互动将 促进概念和实验方法的发展，否则这些方法可能是不可能的。

Microbial Pathogenesis and Host Response September 11 – 15, 2023 ABSTRACT The fourteenth international conference on Microbial Pathogenesis and Host Response will focus on interdisciplinary approaches to study infectious disease, integrating the disciplines of molecular microbiology, eukaryotic cell biology, immunology, and genomics. Microbial diseases have once again taken an important central role in health care worldwide, due to the emergence of new pathogens, the re-ascent of common pathogens, and extensive drug resistance. Outside of human health, devastating pandemics are destabilizing ecosystems, with brown bats and amphibians currently under extreme threat. The meeting will provide an in- depth focus on the approaches that are being used to elucidate the mechanisms of bacterial and fungal pathogenesis, and promote the application of these concepts to novel strategies for the control and intervention of infectious diseases. Oral and poster sessions will focus on major emerging themes of microbial pathogenesis and the host response, including: the pathogenesis of microbial diseases; the molecular regulation of host- pathogen interactions, host cell/pathogen interaction biology, and the diversity of pathogen strategies to evade innate immunity. The sessions will integrate studies on bacterial and fungal pathogens. The oral sessions will begin with 2-3 invited talks by established leaders in the field, followed by several shorter talks chosen from submitted abstracts. Broad themes for individual sessions include: (1) role of microbial toxins and effectors in microbial diseases; (2) fundamental cell biological interactions during infection, (3) innate immune responses to microbial infection’ (4) key molecular regulation of host-microbial interactions; (5) microbial communities in health and disease, and (6) using state-of-the art technologies to visualize host-pathogen interactions. The inclusion of two poster sessions as well as the allotment of ample time for questions following each talk will encourage extensive discussion between the participants. The meeting will be small enough (250-350 scientists) to facilitate these interactions, yet large enough to allow for oral presentations not only from established investigators, but also from junior investigators and those with novel perspectives. The integration of a wide variety of aspects of bacterial and fungal pathogenesis with the host response to pathogens should promote new interdisciplinary interactions that are seldom achieved at other meetings on microbial pathogenesis that are either more narrowly focused or so diverse that the topics are challenging to integrate. The resulting interdisciplinary interactions will facilitate the development of conceptual and experimental approaches that might not otherwise be possible.