Training Program in Cancer Biology

描述(由申请者提供)：癌症生物学培训计划是一个面向博士后和博士后的培训计划，旨在培训研究人员，他们将在研究生涯中专注于与癌症问题特别相关的生物和化学问题。本课程让学员了解人类癌症的基本科学问题和临床问题之间的关系。该计划设在维克森林大学综合癌症中心的癌症生物系；所有培训教师要么是癌症生物系的初级成员，要么是癌症生物学专业的交叉任命人员。交叉任命的人员来自生物化学、化学、皮肤科、基因组学、微生物学、病理学、放射生物学和外科。受训者包括博士前博士后候选人和希望补充其癌症研究培训的博士后或博士后研究员。所有博士前实习生都是维克森林大学研究生院授予的癌症生物学博士学位的候选人。博士后和博士后培训结合了研究、研讨会/研讨会参与以及讲授课程，涵盖DNA损伤和修复、癌细胞生物学、信号转导、细胞周期控制、生化药理学、肿瘤免疫学、基因治疗生物信息学，以及人类癌症临床和流行病学问题的概述。研究由系教员导师监督；具体任务由项目执行委员会进行。培训计划的主要特点包括广泛的指导和评估过程，以及培训教师，他们的积极研究计划与临床和基础科学相结合。该培训计划通过以下方式实现国家癌症研究所的目标：(1)培养有能力在其研究生涯中专注于癌症问题的研究人员；(2)提供跨越化学-生物界面的教育；(3)强调基础科学与人类癌症临床问题之间的联系。培训方案在最初的供资周期内取得了一些显著的成功，并将延续到当前的供资周期，其中包括：(1)显著增加代表不足的少数族裔学员的入学人数；(2)使继续担任学术机构教职的博士后学员毕业；(3)为两名博士后化学家提供生物培训，并为两名博士后癌症生物学学员提供化学培训。

DESCRIPTION (provided by applicant): The Training Program in Cancer Biology is a program for pre- and postdoctoral trainees designed to train investigators who will focus on biological and chemical issues specifically related to the problem of cancer during their research careers. This program imparts to trainees an understanding of the relationships between the basic scientific problems and clinical issues of human cancer. The Program is anchored in the Department of Cancer Biology of the Wake Forest University Comprehensive Cancer Center; all training faculty are either primary Cancer Biology Department members or are cross-appointed in Cancer Biology. Cross appointees come from the Departments of Biochemistry, Chemistry, Dermatology, Genomics, Microbiology, Pathology, Radiation Biology, and Surgery. Trainees include pre-doctoral Ph.D. candidates and Ph.D. or M.D. postdoctoral fellows who wish to supplement their training in cancer research. All pre-doctoral trainees are candidates for a Ph.D. in Cancer Biology conferred by the Graduate School of Wake Forest University. Pre- and postdoctoral traineeships combine research, seminar/symposia participation plus didactic coursework covering DNA damage and repair, cancer cell biology, signal transduction, cell cycle control, biochemical pharmacology, tumor immunology, gene therapy bioinformatics, and an overview of clinical and epidemiologic issues in human cancer. Research is supervised by Departmental faculty mentors; specific assignments are made by the Program executive committee. Key features of the Training Program include an extensive mentoring and evaluation process and a training faculty with active research programs that mesh clinical and basic science. This training program addresses the goals of the National Cancer Institute by: (1) producing investigators equipped to focus on the cancer problem in their research careers; (2) providing education spanning the chemical-biological interface; (3) emphasizing links between basic science and the clinical problems of human cancer. The Training Program achieved some notable successes during its initial funding cycle that will be carried forth into the current funding cycle, including: (1) markedly increasing the enrollment of under-represented minority trainees; (2) graduating postdoctoral trainees who have gone on to faculty positions at academic institutions; (3) providing biological training for two postdoctoral chemists and training in chemistry for two predoctoral Cancer Biology trainees.