Establishing the PhenX Toolkit as a Biomedical Knowledgebase

项目摘要/摘要 PhenX(表型和暴露的共识措施)的目标是为调查人员提供 使用标准的测量方案(例如，问卷、生物测定、身体测量)来改进 数据收集的质量和一致性，增加了个别研究的影响。随着时间的推移，这 共同货币将使调查人员能够更容易地结合研究，以增加统计能力和 比较研究以验证研究结果。启用共享数据分析应该会带来更好的 对人类疾病的病因、进展和治疗的了解，最终导致 改善患者护理、健康结果和生活质量。为此，PhenX建立了一个 免费提供的基于Web的测量方案目录，旨在用于基因组、临床和 人类参与者的翻译和流行病学研究。PhenX工具包内容和 功能是由科学界驱动的。PhenX指导委员会(SC)提供 指南和PhenX工具包中的每个测量方案由以下工作组(WG)选择 专家们使用一种基于共识的过程，依赖于科学界的投入。 该研究计划将PhenX工具包建立为一个可持续的知识库， 积累和注释标准协议，并将它们链接到相关资源和数据。具体来说， 这一行政补编将扩大工具包，以解决医用大麻的使用、多种物质的使用、 和康复。本行政副刊的具体目的是：(1)审查和调整污名化 在药物滥用和添加(SAA)收集中使用的语言，(2)确定 PhenX工具包中的SAA测量协议和其他协议，(3)解决SAA覆盖范围中的差距 与医用大麻的使用、多物质的使用和回收有关，以及(4)向 科学界。这一努力将支持NIDA资助的倡议，提高对工具包作为 宝贵的资源，并吸引更多的用户使用该工具包。广泛采用PhenX措施将 促进交叉研究分析，从而增加个别研究的科学影响。

PROJECT SUMMARY/ABSTRACT The goal of PhenX (consensus measures for Phenotypes and eXposures) is to provide investigators with standard measurement protocols (e.g., questionnaires, bioassays, physical measurements) to improve the quality and consistency of data collection and increase the impact of individual studies. Over time, this common currency will enable investigators to more easily combine studies to increase statistical power and compare studies to validate findings. Enabling analysis of shared data should lead to a better understanding of the etiology, progression, and treatment of human disease, ultimately leading to improvements in patient care, health outcomes, and quality of life. To this end, PhenX has established a freely available, web-based catalog of measurement protocols intended for use in genomic, clinical, translational, and epidemiological research with human participants. The PhenX Toolkit content and features are driven by the scientific community. The PhenX Steering Committee (SC) provides overarching guidance and each measurement protocol in the PhenX Toolkit is selected by a Working Group (WG) of experts using a consensus-based process that relies on input from the scientific community. The research plan will establish the PhenX Toolkit as a sustainable knowledgebase that organizes, accumulates, and annotates standard protocols and links them to relevant resources and data. Specifically, this administrative supplement will expand the Toolkit to address medical cannabis use, polysubstance use, and recovery. The specific aims of this administrative supplement are to (1) review and adjust stigmatizing language in the Substance Abuse and Additions (SAA) collections, (2) identify pertinent linkages among SAA measurement protocols and other protocols in the PhenX Toolkit, (3) address gaps in SAA coverage related to Medical Cannabis Use, Polysubstance Use, and Recovery, and (4) disseminate results to the scientific community. This effort will support NIDA-funded initiatives, raise awareness of the Toolkit as a valuable resource, and attract additional users to the Toolkit. Widespread adoption of PhenX measures will facilitate cross-study analysis, thus increasing the scientific impact of individual studies.