Center for Functional Imaging Technologies

描述（由申请人提供）：在本申请中，我们寻求在P41区域资源，功能神经成像技术中心（CFNT）的高度集成的多模式框架内继续努力开发创新神经成像技术的新的支持。CFNT的总体目标是提供技术资源，以便更仔细地检查和更好地了解健康和疾病中的人类大脑。为此，我们寻求开发新技术并推进现有技术，以前所未有的生理精度和时空分辨率获取和分析工作大脑的功能特定图像。为了实现这一目标，我们建议继续开展我们的核心和合作研究、服务、培训和传播活动。这项工作的核心是我们的四个核心技术研究和开发项目，旨在改进和扩展非侵入性磁共振图像分析（项目1）和采集（项目2）、电磁源成像（项目3）和光学神经成像（项目4）技术。在这个周期中，一项令人兴奋的新技术，集成PET/MRI将在几个项目中进行探索。该资源提供了一个重要的互动环境，在这个环境中，一个由具有多种模式和学科的不同专业知识的高技能科学家、工程师和临床医生组成的跨学科团队与我们的中心密切合作，以提高中心的技术能力，同时通过应用我们共同开发的工具，相互加强他们自己的研究。最后，该资源将继续支持全国神经科学家对中心设施的服务使用，为学生、研究员和工作人员提供广泛的培训机会，并通过积极传播新知识和技术，寻求推动大脑测绘领域的发展。公共卫生相关性：P41资源通过积极开发尖端神经成像技术，开展涉及这些技术应用的合作研究，并将其扩展到更广泛的神经科学研究界，具有帮助塑造基础神经科学和转化研究前景的广泛潜力。最终，这项工作可能会促进新的治疗方法的发展，以治疗一系列令人震惊的神经和精神疾病。

DESCRIPTION (provided by applicant): In this application we seek renewed support for our continued efforts to develop innovative neuroimaging technologies within the highly integrated multimodal framework of our P41 Regional Resource, the Center for Functional Neuroimaging Technologies (CFNT). The overarching goal of the CFNT is to provide technology Resources to more closely examine and better understand the human brain in both health and disease. To this end, we seek to develop new techniques and advance existing technologies for acquisition and analysis of functionally specific images of the working brain, with unprecedented physiological precision and spatiotemporal resolution. To accomplish this goal, we propose to continue our core and collaborative research, service, training and dissemination activities. Central to this effort are our four core technology research and development projects, designed to improve and extend techniques for non-invasive magnetic resonance image analysis (Project 1) and acquisition (Project 2), electromagnetic source imaging (Project 3), and optical neuroimaging (Project 4). New for this cycle, an exciting new technology, integrated PET/MRI will be explored within several of these projects. The Resource provides an essential interactive environment, within which an interdisciplinary team of highly skilled scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines collaborate closely with our Center to advance the technical capabilities of the Center, while reciprocally enhancing their own research by applying the tools we co-develop. Finally, the Resource will continue to support service use of the Center's facilities by neuroscientists throughout the country, provide extensive training opportunities for students, fellows, and staff scientists, and seek to advance the field of brain mapping through active dissemination of new knowledge and technology. PUBLIC HEALTH RELEVANCE: The P41 Resource, by actively developing cutting-edge neuroimaging technologies, conducting collaborative research involving applications of these technologies, and extending them for service use to the broader neuroscientific research community, has extensive potential to help shape the basic neuroscience and translational research landscape. Ultimately, this work may thus facilitate the development of new therapeutic advances for an astounding array of neurological and psychiatric diseases.