Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging

我们建议在体内设计，建造和评估扫描仪接近 放射自显影神经断层扫描（SAVANT），下一代PET扫描仪， 利用硬件进步对人脑进行超高分辨率成像 由我们的合作团队成员开发，以实现前所未有的空间 分辨率和计数率能力。该系统将具有体积分辨率 接近1mm3（各向同性空间分辨率接近1mm），这大约是 比最好的专用脑部PET扫描仪好27倍，比最好的专用脑部PET扫描仪好125倍。 通用PET扫描仪。这种改进将允许可视化和 前所未有地量化体内生理事件，例如 前驱期内嗅皮质中tau神经元缠结的沉积 阿尔茨海默病的阶段和多巴胺转运蛋白浓度 黑质和腹侧被盖区这将允许检测和 在更早的阶段定量脑部疾病，在临床发病前几十年 症状，并允许研究神经递质系统中的关键结构， 目前无法用PET精确成像。建议的高分辨率PET 将在体模研究中对扫描仪进行确认，并在健康 志愿者

We propose to design, build, and evaluate the Scanner Approaching in Vivo Autoradiographic Neuro Tomography (SAVANT), a next generation PET scanner for ultra-high resolution imaging of the human brain using hardware advances developed by members of our collaborative team to achieve unprecedented spatial resolution and count rate capabilities. The system will have a volumetric resolution close to 1 mm3 (isotropic spatial resolution close to 1 mm), which is approximately 27 fold better than the best dedicated brain PET scanners and 125 fold better than general purpose PET scanners. Such an improvement will allow visualization and quantification of in vivo physiological events as never before possible, such as deposition of tau neurofibrillary tangles in the entorhinal cortex in the prodromal stages of Alzheimer's disease and dopamine transporter concentration in the substantia nigra and ventral tegmental area. This will allow the detection and quantitation of brain disease at a much earlier stage, decades before onset of clinical symptoms, and permit the study of key structures in neurotransmitter systems that currently cannot be imaged accurately with PET. The proposed high resolution PET scanner will be validated in phantom studies and performance evaluated in healthy volunteers.