Bioinformatics Core

项目摘要 PDTC生物信息学核心是PDTC的关键集成点，将提供专业知识， 我们只解释与我们的PDX和类器官模型相关的复杂组学数据， 鉴定与药物反应正相关或负相关的肿瘤分子特征的专业知识。 PDTC生物信息学核心的目标是： 1.提供研究项目之间的主要整合点，因为生物信息学核心将 对两个研究项目的数据进行互补分析，以进行交叉比较。 2.为实验设计提供统计建模，特别是关于动物 临床前试验及其分析，用于研究项目和试点项目， 现有的两个机构核心在HCI和IBM。 3.从机构核心设施（如标准组学数据/管道）和直接从 研究项目和PDTC PDX核心（例如药物反应数据）以及公共数据 数据库，以执行组学和药物反应数据的分析。 4.最大限度地利用现有的两个机构核心-人道主义行动和人道主义行动的支助， 使用患者衍生模型，包括软件和数据库开发。 5.继续开发实验设计和分析的新方法， 在HCI和IBM以及整个PDXNet上实现。 6.为了促进HCI和PDM之间的数据组织和交换，以及通过 PDX数据共享和协调中心。 7.合作完成研究项目的数据分析、结果解释和期末报告的撰写 研究报告和手稿。

Project Summary The PDTC Bioinformatics Core is a key integration point of the PDTC, and will provide the expertise to not only interpret complex omics data that is already associated with each of our PDX and organoid models, but also the expertise to identify molecular features of tumors that positively or negatively correlate with drug responses. The goals of the PDTC Bioinformatics Core are: 1. Provide a major point of integration between Research Projects, since the Bioinformatics Core will be applying complementary analyses to data from both Research Projects for cross-comparison. 2. To provide statistical modeling for experimental design, particularly with respect to animal preclinical trials and their analyses, for both Research Projects and Pilot Projects in conjunction with the two existing institutional cores at HCI and BCM. 3. To import data from institutional core facilities (e.g. standard omics data/pipelines) and directly from Research Projects and the PDTC PDX Core (e.g. drug response data), as well as from public data repositories, in order to perform analysis of omics and drug response data. 4. To maximize use of support from the two existing institutional cores at HCI and BCM in support of work with patient-derived models, including software and database development. 5. To continue to develop novel approaches for experimental design and analytics that can be implemented at HCI and BCM, and across the PDXNet. 6. To facilitate data organization and exchange between HCI and BCM, and across the PDXNet via the PDX Data Commons and Coordinating Center. 7. To collaborate in research projects’ data analysis, interpretation of results, and the writing of final study reports and manuscripts.