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Analysis of cancer-related immune suppressor mechanisms in mice

Analysis of cancer-related immune suppressor mechanisms in mice
小鼠癌症相关免疫抑制机制分析
批准号：
10014631
负责人：
Tim Greten
金额：
$169.3万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10014631
关键词：
Animal ModelBile AcidsCell physiologyCellsCirrhosisFatty LiverImmuneImmune responseImmunologic MonitoringImmunotherapyImpairmentInfectionInflammationLiverLiver diseasesMalignant NeoplasmsMusPortal vein structureTestingTumor Escapeabsorptiongut microbiomeimmunoregulationmicrobiometumortumor growth

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中文摘要
翻译
已经表明，肿瘤已经发展出许多方式来逃避肿瘤特异性免疫应答。这些机制最终不仅会促进肿瘤生长，还会削弱基于免疫的癌症治疗的效果。在过去的一年里，我们完成了一项研究，显示肠道微生物组如何控制肠道中的胆汁酸，而胆汁酸在吸收到门静脉后又控制了NKT细胞在肝脏中的积累。这些细胞在几种动物模型中控制肿瘤生长，我们目前正在测试这些细胞的免疫功能调节
英文摘要
It has been shown that tumors have developed numerous ways to escape tumor specific immune responses. These mechanisms will ultimately not only enhance tumor growth, but also impair the effect of immune based therapies in cancer. In the past year we were able to complete a study showing how the gut microbiome controls bile acids in the gut, which in turn after absorption into the portal vein control accumulation of NKT cells in the liver. These cells control tumor growth in several animal models and we are currently testing the regulation of immune function of these cells
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Center for Cell-based Therapy - Cures
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