PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients

我们已获得IRB批准，将于2018年7月开始招募患者。我们于2018年11月20日开始成像。我们已经招募了总共18名接受过一次扫描(仅FDOPA扫描，n=1，仅DASB扫描，n=1)或两次扫描(FDOPA和DASB，n=16)的受试者 成像多巴胺能系统： 1.A组：9例经DR Avi nath全手筛查的HIV感染者。 2.B组：来自Dr Avi nath的0名未感染HIV的受试者，所有人都进行了队列筛查，且至少有一例合并发病 3.C组：7例DR Avi nath无HIV感染且无合并症的人群筛查队列。 5-羟色胺转运体的成像(使用11C-DASB的SERT。他们也将从纳特博士的全员方案中招募。 1.D组：8例经DR Avi nath全手筛查的HIV感染者。 2.E组：DR Avi nath全员筛查队列中未发现HIV感染的患者8例。 数据分析：我们目前正在分析数据(操作员分组盲法)，即量化所有受试者大脑中的FDOPA和DASB摄取。我们将在2019年底之前进行中期分析。在这一点上，我们将集中招募艾滋病病毒阴性并患有共病的受试者，以使所有群体的人数相等。

We have received IRB approval to start recruiting patients in July 2018. We started imaging on 11/20/2018. We have already recruited a total of 18 subjects who have undergone one scan (Only FDOPA scan, n=1, only DASB scan, n=1) or two scans (FDOPA and DASB, n= 16) Imaging the dopaminergic system: 1. Group A: 9 patients with HIV infection from Dr Avi Naths All Hands screening cohort. 2. Group B: 0 subjects without HIV infection from Dr Avi Naths All Hands screening cohort AND with at least one co-morbidity 3. Group C: 7 patients without HIV infection from Dr Avi Naths All Hands screening cohort AND without co-morbidities. Imaging of the Serotonin transporter (SERT using 11C-DASB. they will also be recruited from Dr Nath's all hands protocol. 1. Group D: 8 patients with HIV infection from Dr Avi Naths All Hands screening cohort. 2. Group E: 8 patients without HIV infection from Dr Avi Naths All Hands screening cohort. Data analysis: we are currently analyzing the data (operator blinded for group) namely quantifying FDOPA and DASB uptake in the brain of all our subjects. We will proceed with an interim analysis before the end of 2019. We will concentrate on recruiting HIV negative subjects with co-morbidities at this point to have equal numbers in all groups.