MRI and X-ray catheter design and prototyping

在过去的一年中，我们继续致力于开发磁共振成像（MRI）兼容和可视设备，以执行计划在MRI下执行的腔内介入手术。 我们发明了一种新型分段血管导丝，有望克服以前器械的许多安全性和机械缺陷。我们已经优化了设计，并开发了一个质量体系，以允许首次人体测试，我们也预计在未来一年。 我们与Bogazici大学和格鲁吉亚理工学院合作开发微型电子产品的新制造技术，以实现安全和引人注目的MRI设备，特别是用于人类应用的针形天线。 这些技术已经成功地生成了MRI可见标记，其不需要会限制微创治疗性能的超大设备。 我们已经取得了进展，对一种新的光声MRI导管传输线，承诺进一步提高MRI导管的安全性。 我们已经发明了几种一流的介入器械，用于新型治疗性非外科手术。 这些包括用于基于经心房导管的三尖瓣修复术的器械、经腔静脉进入主动脉以使没有良好选择的患者能够进行经导管主动脉瓣置换术、非手术进入左心房、新型血管导引鞘和非手术先天性心脏病的解剖外旁路。 其中许多包括新型医疗器械的发明和专利申请，例如用于经腔静脉进入主动脉的专用闭合器械。 我们还与行业合作，将我们的实验室发明转化为私营部门的病人护理。 我们与一家大型导管公司签订了合作研发协议，与小型导管公司签订了研究协议，共同开发一些设备。 我们还赞助了我们内部实验室的小企业创新研究合同，以指导新的高风险技术通过小企业进入临床测试。

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have invented a novel segmented vascular guidewire that promises to overcome many of the safety and mechanical shortcomings of previous devices. We have optimized the design and developed a quality system to allow first-in-human testing, which we also expect in the upcoming year. We collaborate with Bogazici University and Georgia Institute of Technology to develop new manufacturing techniques for microminiature electronics to enable safe and conspicuous MRI devices, especially a needle antenna for human application. These techniques have succeeded in generating a MRI visible marker that does not require an oversized device that would limit performance in minimally-invasive therapies. We have made inroads towards a novel optoacoustical MRI catheter transmission line which promises further to enhance the safety of MRI catheters. We have invented several first-in-class interventional devices for novel therapeutic non-surgical procedures. These include devices for trans-atrial catheter-based tricuspid valve repair, transcaval access to the aorta to enable transcatheter aortic valve replacement in patients with no good options, non-surgical access to the left atrium, novel vascular introducer sheaths, and extra-anatomic bypass for congenital heart disease without surgery. Many of these include inventions and patent applications for novel medical devices, such as purpose-built closure devices for transcaval access to the aorta. We also work with industry to translate our laboratory inventions into the private sector for patient care. We have entered into collaborative research and development agreements with a large catheter company, research agreements with small catheter company to co-develop some devices. We also have sponsored Small Business Innovation Research contracts from our intramural laboratory to shepherd novel high-risk technology through small businesses into clinical testing.