New candidate vaccines to prevent tuberculosis: preclinical assessment of efficacy, safety and mechanism of protection
New candidate vaccines to prevent tuberculosis: preclinical assessment of efficacy, safety and mechanism of protection
批准号:
nhmrc : 1043519
负责人:
A/Pr James Triccas
金额:
$39.62万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2016-12-31
中文摘要
每年有近200万人死于结核病。目前的卡介苗在控制结核病方面无效,而且人们对预防这种疾病所需的免疫反应类型知之甚少。我们已经发现了结核病细菌的新抗原,我们将把它们与我们的创新疫苗技术结合起来,开发控制结核病的新疫苗。我们还将尝试了解为什么卡介苗无效,并利用这些信息进一步改善结核病疫苗接种。
英文摘要
Almost two million people die from tuberculosis (TB) each year. The curent vaccine, BCG, is ineffective at controlling TB and and the type of immune response needed to protect against the disease is poorly understood. We have discovered new antigens of the TB bacterium, and we will combine them with our innovative vaccine technology to develop new vaccines to control TB. We will also try and understand why BCG is not effective, and use this information to further improve TB vaccination.
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会议论文
Multistage vaccines for the prevention of tuberculosis
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批准号:nhmrc : 1102597
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项目类别:Project Grants
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资助金额:$60.84万
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财政年份:2016
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负责人:A/Pr James Triccas
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依托单位:
A new class of inhibitors for the treatment of tuberculosis
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批准号:nhmrc : 1084266
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项目类别:Project Grants
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资助金额:$48.06万
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财政年份:2015
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负责人:A/Pr James Triccas
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依托单位:
Genes of Mycobacterium tuberculosis essential for Latent Tuberculosis Infection
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批准号:nhmrc : 1051246
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项目类别:Project Grants
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资助金额:$39.35万
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财政年份:2013
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负责人:A/Pr James Triccas
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依托单位:
Tuberculosis control:from discovery to public health practice and policy
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批准号:nhmrc : 1043225
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项目类别:Centres of Research Excellence
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资助金额:$174.14万
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财政年份:2012
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负责人:A/Pr James Triccas
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依托单位:
Impact of Influenza A infection on T cell-mediated immunity to pulmonary tuberculosis.
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批准号:nhmrc : 1011027
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项目类别:NHMRC Project Grants
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资助金额:$32.54万
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财政年份:2011
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负责人:A/Pr James Triccas
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依托单位:
Visualisation of gamma-delta T cell responses in cutaneous inflammation
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批准号:nhmrc : 632706
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项目类别:NHMRC Project Grants
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资助金额:$38.07万
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财政年份:2010
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负责人:A/Pr James Triccas
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依托单位:
Chronic bacterial infection and the generation of T cell memory: implication for vaccination against tuberculosis
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批准号:nhmrc : 570768
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项目类别:NHMRC Project Grants
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资助金额:$36.54万
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财政年份:2009
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负责人:A/Pr James Triccas
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依托单位:
Regulation of pulmonary immune responses to subunit vaccines against tuberculosis
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批准号:nhmrc : 512269
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项目类别:NHMRC Project Grants
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资助金额:$33.95万
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财政年份:2008
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负责人:A/Pr James Triccas
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依托单位:
Identifying determinants of mycobacterial pathogenesis and understanding host immunity for devel. of novel anti-TB vaccine
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批准号:nhmrc : 402737
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项目类别:Career Development Fellowships
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资助金额:$31.73万
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财政年份:2006
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负责人:A/Pr James Triccas
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依托单位:
Manipulating immunity to Mycobacterium tuberculosis with novel vaccines and immunotherapeutics
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批准号:nhmrc : 402728
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项目类别:NHMRC Project Grants
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资助金额:$34.99万
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财政年份:2006
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负责人:A/Pr James Triccas
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依托单位:
Molecular approaches to developing subunit vaccines with improved efficacy against tuberculosis
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批准号:nhmrc : 302112
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项目类别:NHMRC Project Grants
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资助金额:$32.06万
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财政年份:2004
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负责人:A/Pr James Triccas
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依托单位:
Attenuated and recombinant mycobacterial strains as novel vaccines to control tuberculosis
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批准号:nhmrc : 226920
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项目类别:NHMRC Project Grants
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资助金额:$24.7万
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财政年份:2003
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负责人:A/Pr James Triccas
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依托单位:
identification of genes expressed by mycobacterium tuberculosis to enhance intracellular survival
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批准号:nhmrc : 997142
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项目类别:Early Career Fellowships
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资助金额:$12.99万
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财政年份:1999
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负责人:A/Pr James Triccas
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依托单位:
国内基金
海外基金
短QT综合征新致病基因的定位研究
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批准号:30771183
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项目类别:面上项目
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资助金额:8.0万元
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批准年份:2007
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负责人:吕利雄
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依托单位: